眼底动脉超声血流参数在糖尿病视网膜病变中的评估价值

Evaluation Value of Fundus Artery Colour Ultrasound Blood Flow Parameters in Diabetes Retinopathy

目的探讨眼底动脉超声血流参数在糖尿病视网膜病变中的评估价值。方法回顾性研究,选取安阳市眼科医院于2021年3月至2022年11月收治的98例糖尿病视网膜病变患者为研究对象,依据糖尿病视网膜病变的严重程度,将98例患者分为78例非增生型糖尿病视网膜病变(NPDR)组和20例增生型糖尿病视网膜病变(PDR)组,另选择同期至安阳市眼科医院进行眼底动脉超声检查的30例无视网膜病变糖尿病患者为对照组。通过查阅病历记录所有患者年龄、糖尿病家族遗传史、体重、吸烟史等资料;通过查阅眼底动脉超声检查的结果,记录所有患者眼动脉、视网膜中央动脉、睫状后短动脉的收缩期峰值血流速度(PSV)、舒张期末期血流速度(EDV)、阻力指数(RI)。绘制受试者工作特征(ROC)曲线,分析眼底动脉超声血流参数评估糖尿病视网膜病变的价值。结果3组间眼压对比,PDR组>NPDR组>对照组,差异有统计学意义(P<0.05)。3组间眼动脉、视网膜中央动脉、睫状后短动脉的PSV、EDV对比,对照组>NPDR组>PDR组;3组间眼动脉、视网膜中央动脉、睫状后短动脉的RI对比,对照组<NPDR组<PDR组,差异有统计学意义(P<0.05)。绘制ROC曲线,结果显示,眼动脉PSV、眼动脉EDV、眼动脉RI、视网膜中央动脉PSV、视网膜中央动脉EDV、视网膜中央动脉RI、睫状后短动脉PSV、睫状后短动脉EDV、睫状后短动脉RI评估糖尿病视网膜病变严重程度的曲线下面积(AUC)分别为0.844、0.731、0.881、0.761、0.808、0.817、0.775、0.755、0.818,具有一定的评估价值。结论随着糖尿病视网膜病变的发生及加重,PSV、EDV、RI等眼底动脉超声血流参数呈异常变化,且其在NPDR与PDR的评估中具有较高价值。

Objective To evaluate the value of fundus artery colour ultrasound blood flow parameters in diabetes retinopathy.Methods A retrospective study was conducted to select 98 patients with diabetes retinopathy who were admitted to Anyang Eye Hospital from March 2021 to November 2022.According to the severity of diabetes retinopathy,98 patients were divided into 78 non-proliferative diabetic retinopathy(NPDR)group and 20 proliferative diabetic retinopathy(PDR)group.In addition,30 patients with diabetes who ignored omental lesions and went to Anyang Eye Hospital for fundus artery colour ultrasound examination at the same time were selected as the control group.All patients’age,family genetic history of diabetes,weight,smoking history and other information were recorded by consulting medical records.The peak systolic blood flow velocity(PSV),end-diastolic blood flow velocity(EDV)and resistance index(RI)of the ophthalmic artery,central retinal artery and short posterior ciliary artery in all patients were recorded by consulting the results of fundus artery colour ultrasound examination.The receiver operating characteristic(ROC)curve was drawn to analyze the value of fundus artery colour ultrasound blood flow parameters in evaluating diabetes retinopathy.Results Comparison of intraocular pressure among the three groups,PDR group>NPDR group>control group,with a statistical significant difference(P<0.05).The PSV and EDV of ophthalmic artery,central retinal artery and short posterior ciliary artery were compared among the three groups,the control group>NPDR group>PDR group.The RI of ophthalmic artery,central retinal artery and short posterior ciliary artery was compared among the three groups,the control group<NPDR group<PDR group,with a statistical significant difference(P<0.05).The ROC curve was drawn.The results showed that the area under the curve(AUC)of ophthalmic artery PSV,ophthalmic artery EDV,ophthalmic artery RI,central retinal artery PSV,central retinal artery EDV,central retinal artery RI,short posterior ciliary artery PSV,short posterior ciliary artery EDV,short posterior ciliary artery RI to assess the severity of diabetes retinopathy was 0.844,0.731,0.881,0.761,0.808,0.817,0.775,0.755,0.818,respectively,and it had certain evaluation value.Conclusion With the occurrence and aggravation of diabetes retinopathy,the ultrasonic blood flow parameters of fundus arteries such as PSV,EDV and RI show abnormal changes,and they have high value in the evaluation of NPDR and PDR.