压迫疗法对紫杉醇致周围神经病变的效果

Effect of compression therapy on paclitaxel-induced peripheral neuropathy

目的探讨压迫疗法对预防紫杉醇致周围神经病变(PIPN)的效果。方法选取2018年5月至2020年4月福建省肿瘤医院收治的130例肺癌化疗患者作为研究对象,采用随机数字表法分为实验组(n=61)与对照组(n=62)。对照组采用常规护理措施,实验组在对照组护理基础上佩戴外科手套和弹力袜进行压迫疗法。比较两组PIPN严重程度及手背温度。结果实验组紫杉醇剂量改变占比为19.7%,低于对照组的38.7%,差异有统计学意义(P<0.05)。第2次、第4次化疗及化疗后3个月,实验组PIPN严重程度均低于对照组,差异有统计学意义(P<0.05)。第2次、第4次化疗佩戴手套前,两组右手手背温度比较差异无统计学意义;摘除手套后,实验组手背温度低于佩戴手套前和对照组,差异有统计学意义(P<0.05)。结论压迫疗法具有安全、耐受性好的特点,可降低PIPN的发生率,有利于肺癌患者完成化疗计划。

Objective To investigate the effect of compression therapy on the prevention of paclitaxel-induced peripheral neuropathy(PIPN).Methods 130 patients with lung cancer treated with chemotherapy in Fujian Cancer Hospital from May 2018 to April 2020 were selected as the study subjects,and they were divided into the experimental group(n=61)and the control group(n=62)according to random number table method.The control group received routine nursing measures,and the experimental group wore surgical gloves and elastic socks for compression therapy on the basis of control group nursing.The severity of PIPN and the temperature of the back of hand were compared between the two groups.Results The dose change of paclitaxel in the experimental group was 19.7%,which was lower than 38.7%in the control group,and the difference was statistically significant(P<0.05).The severity of PIPN in the experimental group was better than that in the control group at the second and fourth chemotherapy and 3 months after chemotherapy,and the differences were statistically significant(P<0.05).Before wearing gloves at the second and fourth chemotherapy treatments,there was no significant difference in the temperature of the right hand back between the two groups;after removing gloves,the temperature of the experimental group was lower than that before wearing gloves and the control group,and the differences were statistically significant(P<0.05).Conclusion The compression therapy is safe and well tolerated,can reduces the incidence of PIPN,and is conducive to the completion of chemotherapy in lung cancer patients.