功能康复训练联合盐酸多奈哌齐对轻中度帕金森病痴呆患者的影响

Effect of Functional Rehabilitation Training Combined with Donepezil Hydrochloride on Patients with Mild to Moderate Parkinson's Disease Dementia

目的研究与分析功能康复训练联合盐酸多奈哌齐治疗在轻中度帕金森病痴呆(PDD)患者中的疗效。方法选取2019年12月至2022年12月河南科技大学第一附属医院接诊的轻中度帕金森病痴呆(PDD)患者,共78例PDD。采用随机抽样法划分为参照组和研究组,参照组中为患者提供盐酸多奈哌齐治疗(n=39),研究组在上述基础上提供功能康复训练(n=39),对比各组中患者治疗的认知功能、采用帕金森病评分量表(UPDRS)评价PDD严重程度、临床治疗效果、生活质量。结果患者认知功能评分对比,治疗前,差异无统计学意义(P>0.05),治疗后认知功能评分均有所升高,且研究组高于参照组,差异有统计学意义(P<0.05);UPDRS治疗前各维度评分对比,差异无统计学意义(P>0.05),治疗后评分均有所降低,且研究组低于参照组,差异有统计学意义(P<0.05);研究组的临床治疗效果有效率高于参照组,差异有统计学意义(P<0.05);治疗前患者生活质量评分各维度对比,差异无统计学意义(P>0.05),治疗后生活质量评分均有所提高,且研究组生活质量评分高于参照组,差异有统计学意义(P<0.05)。结论功能康复训练与盐酸多奈哌齐的联合使用,有效改善了轻中度PDD患者认知功能,缓解病情,并且促使其生活质量提高。

Objective To study and analyze the efficacy of functional rehabilitation training combined with Donepezil hydrochloride in the treatment of mild to moderate Parkinson's disease dementia(PDD)patients.Methods A total of 78 patients with mild to moderate Parkinson's disease dementia(PDD)were selected from the First Affiliated Hospital of Henan University of Science and Technology from December 2019 to December 2022.According to random sampling method,the reference group was treated with donepezil hydrochloride(n=39);the research group was treated with the functional rehabilitation training and donepezil hydrochloride(n=39).The cognitive function of patients in each group was compared,and the severity of PDD,clinical treatment effect and quality of life were evaluated by Parkinson's Disease Score Scale(UPDRS).Results The cognitive function scores of patients showed no statistical significance before treatment(P>0.05),while the cognitive function scores of patients increased after treatment,and the study group was higher than the reference group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the scores of all dimensions before UPDRS treatment(P>0.05),and the scores were decreased after treatment,and the study group was lower than the reference group,with statistical significance(P<0.05).The clinical efficacy of the study group was higher than that of the reference group,the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in all dimensions of quality of life score(P>0.05),but after treatment,quality of life score of the study group was improved,and quality of life score of the study group was higher than that of the reference group,the difference was statistically significant(P<0.05).Conclusion The combination of functional rehabilitation training and Donepezil hydrochloride can effectively improve the cognitive function of patients with mild to moderate PDD,alleviate the disease,and promote the quality of life.