胃蛋白酶原、胃泌素-17和幽门螺杆菌定量检测在胃癌早期筛查中的应用

Application of quantitative detection of pepsinogen,gastrin-17,and Helicobacter pylori in early screening of gastric cancer

目的 探究胃蛋白酶原(PG)、胃泌素-17 (GAS-17)及幽门螺杆菌(Hp)定量检测在胃癌早期筛查中的应用价值。方法 选取2018年10月至2022年10月期间西安医学院附属宝鸡医院收治的94例疑似胃癌患者作为研究对象,所有患者均接受PG (PGⅠ、PGⅡ)、GAS-17及Hp定量检测;以病理学检查作为胃癌诊断的金标准,将患者分为胃癌组(n=39)和非胃癌组(n=55),绘制受试者工作特征曲线(ROC)分析PG、GAS-17及Hp定量检测评估原发性胃癌的曲线下面积(AUC)、灵敏度和特异度。结果 胃癌组患者的PGⅠ水平为(78.34±12.68) ng/m L,明显低于非胃癌组的(106.37±18.27) ng/m L,PGⅡ、GAS-17及Hp定量检测水平分别为(21.34±4.56) ng/m L、(23.51±6.84) pmol/L、(286.39±51.36) dmp,明显高于非胃癌组的(17.26±3.77) ng/mL、(13.44±4.25) pmol/L、(185.47±46.32) dmp,差异均有统计学意义(P<0.05);经ROC分析结果显示,PGⅠ、PGⅡ、GAS-17及Hp定量检测应用于早期胃癌筛查的AUC分别为0.926、0.711、0.918、0.919,灵敏度分别为92.31%、74.36%、84.62%、92.31%,特异度分别为81.82%、58.18%、83.64%、76.36%。结论 PG、GAS-17以及Hp定量检测应用于胃癌早期筛查均具有一定的参考价值,值得临床工作者借鉴。

Objective To explore the application value of pepsinogen(PG),gastrin-17(GAS-17),and Helicobacter pylori(Hp)in the early screening of gastric cancer.Methods A total of 94 patients with suspected gastric cancer admitted to Baoji Hospital Affiliated to Xi'an Medical College from October 2018 to October 2022 were selected as the research objects.All patients received quantitative detection of PG(PGⅠ,PGⅡ),GAS-17,and Hp.The pathological examination was used as the gold standard for the diagnosis of gastric cancer.The patients were divided into gastric cancer group(n=39)and non-gastric cancer group(n=55).The receiver operating characteristic curve(ROC)was drawn to analyze the area under the curve(AUC),sensitivity,and specificity of PG,GAS-17,and Hp quantitative detection in evaluating primary gastric cancer.Results The level of PGⅠin the gastric cancer group was(78.34±12.68)ng/mL,which was significantly lower than(106.37±18.27)ng/mL in the non-gastric cancer group;the quantitative detection levels of PGⅡ,GAS-17,and Hp were(21.34±4.56)ng/mL,(23.51±6.84)pmol/L,(286.39±51.36)dmp,respectively,which were significantly higher than(17.26±3.77)ng/mL,(13.44±4.25)pmol/L,(185.47±46.32)dmp in the non-gastric cancer group;the differences were statistically significant(P<0.05).The results of ROC analysis showed that the AUC of PGⅠ,PGⅡ,GAS-17,and Hp quantitative detection in early gastric cancer screening was 0.926,0.711,0.918,and 0.919;the sensitivity was 92.31%,74.36%,84.62%,and 92.31%,respectively;the specificity was 81.82%,58.18%,83.64%,and 76.36%.Conclusion The quantitative detection of PG,GAS-17,and Hp has certain reference value in the early screening of gastric cancer,which is worthy of reference for clinical workers.