芪芩乌贝清化饮联合常规西药治疗幽门螺杆菌感染慢性胃炎脾胃湿热证患者的疗效观察

Observation on Therapeutic Effect of QiqinWubeiQinghua Decoction Combined with Conventional Western Medicine in Patients with Chronic Gastritis Infected by Heli⁃cobacter Pylori with Dampness-Heat Syndrome of Spleen and Stomach

目的探讨芪芩乌贝清化饮联合常规西药治疗幽门螺杆菌(Helicobacter pylori,Hp)感染慢性胃炎脾胃湿热证的临床疗效。方法选取2020年1月—2022年6月期间中国人民解放军联勤保障部队第九OO医院收治的幽门螺杆菌感染慢性胃炎脾胃湿热证患者120例,按随机数字表法分为对照组和试验组,每组各60例。对照组给予常规西药治疗,试验组在对照组基础上联合芪芩乌贝清化饮治疗。治疗4周后,观察比较两组患者临床疗效、幽门螺杆菌(Helicobacter pylori,Hp)清除率、不良反应,治疗前后中医证候主症、次症积分、胃肠功能评分(Gastrointestinal Function Score,GSRS-C)。结果治疗后两组患者脾胃湿热证中医证候主症、次症积分均较治疗前降低,差异有统计学意义(P<0.05);且试验组脾胃湿热证中医证候主症、次症积分均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者GSRS-C评分均较治疗前降低,差异有统计学意义(P<0.001);且试验组GSRS-C评分明显低于对照组,差异有统计学意义(P<0.001)。治疗后试验组治疗总有效率93.33%(56/60)明显高于对照组79.31%(46/58),差异有统计学意义(P<0.05)。治疗后试验组Hp根除率91.67%(55/60)明显高于对照组74.14%(43/58),差异有统计学意义(P<0.05)。治疗期间,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论芪芩乌贝清化饮联合常规西药治疗慢性胃炎脾胃湿热证效果显著、安全性高,能够提高Hp根除率,改善患者胃肠功能。

Objective To explore the clinical effect of QiqinWubeiQinghua Decoction combined with conventional Western medicine in the treatment of chronic gastritis infected by(helicobacter pylori)Hp with dampness-heat syndrome of spleen and stomach.Methods A total of 120 cases of patients with chronic gastritis infected by Hp with dampness-heat syndrome of spleen and stomach in the Ninth Hospital of the PLA Joint Logistic Support Force from January 2020 to June 2022 were selected and divided by random number table method.The control group and test group were set,with 60 cases in each group.The control group was treated with conventional Western medicine,and the test group was treated with QiqinWubeiQinghua Decoction on this basis.After four weeks of treatment,the clinical efficacy,Hp eradication rate,ad⁃verse reactions,scores of main symptoms and secondary symptoms of TCM,and gastrointestinal function score(GSRS-C)before and after treatment were observed and compared between the two groups.Results After treatment,the scores of main symptoms and secondary symptoms of TCM of patients with dampness-heat syndrome of spleen and stomach in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).The scores of the main and secondary symptoms of the TCM of patients with dampness-heat syndrome of spleen and stomach in the test group were lower than those in the control group(P<0.05).The GSRS-C score of the two groups after treatment was lower than that before treatment(P<0.001),and the test group was lower than the control group(P<0.001).After treat⁃ment,the total effective rate of the test group was 93.33%(56/60),which was significantly higher than 79.31%(46/58)of the control group(P<0.05).The Hp eradication rate of the test group was 91.67%(55/60),which was significantly higher than 74.14%(43/58)of the control group(P<0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion QiqinWubeiQinghua Decoction combined with conven⁃tional Western medicine is effective and safe in the treatment of chronic gastritis with dampness-heat syndrome of spleen and stomach,which is beneficial to increase Hp eradication rate and improve the gastrointestinal function of patients.