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通窍耳聋丸治疗老年性耳聋耳鸣的疗效研究

Study on the efficacy of Tongqiao Erlong Pills on senile deafness and tinnitus
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摘要 目的探讨通窍耳聋丸治疗老年性耳聋耳鸣的疗效及安全性。方法180例老年性耳聋耳鸣患者,随机分为对照组和观察组,每组90例。对照组采用舒血宁注射液和长春胺缓释胶囊改善循环,胞磷胆碱钠胶囊营养神经;观察组在对照组的基础上加用通窍耳聋丸。比较两组患者的耳聋及耳鸣疗效、治疗前后的耳鸣致残量表(THI)评分、不良反应发生情况,不同耳聋程度患者治疗前后的听力阈值。结果观察组耳聋及耳鸣的治疗总有效率分别为93.33%和92.22%,高于对照组的81.11%和82.22%,差异具有统计学意义(P<0.05)。治疗后,两组轻度、中度、中重度、重度、极度耳聋患者的听力阈值均低于本组治疗前,差异具有统计学意义(P<0.05);且观察组中度、中重度、重度耳聋患者的听力阈值降低值分别为(17.96±8.54)、(16.97±9.66)、(20.61±10.33)dBHL,大于对照组的(12.75±4.54)、(11.67±5.66)、(14.98±6.33)dBHL,差异具有统计学意义(P<0.05)。治疗后,两组患者的THI评分均低于本组治疗前,且观察组患者低于对照组,差异具有统计学意义(P<0.05);观察组患者的THI评分值降低值为(17.70±1.92)分,大于对照组的(12.17±2.12)分,差异具有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论通窍耳聋丸联合改善循环营养神经的西药治疗老年性耳聋耳鸣具有较好的有效性和安全性,值得临床推广。 Objective To discuss the efficacy and safety of Tongqiao Erlong Pills on senile deafness and tinnitus.Methods A total of 180 senile patients with deafness and tinnitus were randomly divided into the control group and the observation group,with 90 cases in each group.The control group received Shuxuening injection and vincamine sustained-release capsule to improve circulation,citicoline sodium capsule to nourish nerves;the observation group was given Tongqiao Erlong Pills on the basis of the control group.Both groups were compared in terms of efficacy of deafness and tinnitus,the score of tinnitus handicap inventory(THI)before and after treatment,the occurrence of adverse reactions,and the hearing threshold of patients with different degrees of deafness before and after treatment.Results The total effective rate of deafness and tinnitus in the observation group were 93.33%and 92.22%,which were higher than those of 81.11%and 82.22%in the control group,and the differences were statistically significant(P<0.05).After treatment,the hearing thresholds of patients with mild,moderate,moderate,severe and extreme deafness in both groups were lower than those before treatment in this group,and the differences were statistically significant(P<0.05).In the observation group,the hearing threshold reduction of patients with moderate,moderate and severe deafness were(17.96±8.54),(16.97±9.66)and(20.61±10.33)dBHL,which were higher than those of(12.75±4.54),(11.67±5.66)and(14.98±6.33)dBHL in the control group,and the differences were statistically significant(P<0.05).After treatment,THI score in both groups were lower than that before treatment in this group,and the observation group was lower than the control group.The differences were statistically significant(P<0.05).THI score in the observation group decreased by(17.70±1.92)points,which was greater than that of(12.17±2.12)points in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Tongqiao Erlong Pills combined with Western medicine to improve the circulation of nutritional nerves in the treatment of senility deafness and tinnitus has high effectiveness and safety,and is worthy of clinical promotion.
作者 晏红兵 周颖奇 YAN Hong-bing;ZHOU Ying-qi(Department of Otolaryngology,Xiaochang First People's Hospital,Xiaogan 432900,China)
出处 《中国实用医药》 2023年第21期151-154,共4页 China Practical Medicine
关键词 耳聋 耳鸣 通窍耳聋丸 老年 Deafness Tinnitus Tongqiao Erlong Pills Old age
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