母体免疫调节与妊娠诱导缓解的疾病的关系

The relationship between maternal immunomodulation and pregnancy-induced remission of disease

妊娠是女性的特殊阶段,临床发现部分以育龄期女性多发的疾病,如类风湿关节炎、多发性硬化、银屑病及偏头痛,在妊娠期病情会自然缓解,尤其在妊娠中晚期,疾病活动度显著下降,与妊娠期免疫耐受的变化时相一致。因此,妊娠期独特的免疫调节机制可能是这些疾病在妊娠期缓解的重要原因,此外,妊娠期高浓度的激素作用等对这些疾病的改善也具有重要作用。本文主要关注妊娠期母体对疾病的调节作用,尤其是妊娠诱导的免疫调节机制。

Pregnancy is a special stage for women,and it has been clinically found that some diseases prevalent in women of reproductive age,such as rheumatoid arthritis,multiple sclerosis,psoriasis,and migraine,remit naturally during pregnancy,especially during mid to late pregnancy,disease activity decreases significantly,consistent with changes in immune tolerance during pregnancy.Therefore,the unique immunomodulatory mechanism of pregnancy may be an important reason for the remission of these diseases during pregnancy.In addition,the high hormonal effects during pregnancy also play important roles in the improvement of these diseases,and this paper mainly focuses on the modulatory effects of the maternal pregnancy on the diseases,especially the pregnancy-induced immunomodulatory mechanisms.