妊娠期高血压疾病患者外周血PLGF、NEFA、Hcy水平的检测意义

Detection significance of placental growth factor,nonestesterified fatty acid and homocysteine levels in peripheral blood of patients with hypertensive diseases during pregnancy

目的探究妊娠期高血压疾病(HDCP)患者外周血游离脂肪酸(NEFA)、胎盘生长因子(PLGF)、同型半胱氨酸(Hcy)水平的检测意义。方法选取海南现代妇女儿童医院2019年6月至2022年6月就诊的200例HDCP患者作为观察组,另选取同期产前检查的60例健康孕妇作为对照组,检测并比较两组外周血PLGF、NEFA、Hcy水平。结果观察组外周血PLGF水平较对照组低,NEFA、Hcy水平较对照组高(P<0.05);外周血PLGF水平与HDCP病情程度呈负相关,外周血NEFA、Hcy水平与HDCP病情程度呈正相关(P<0.05);外周血PLGF、NEFA、Hcy水平预测HDCP患者妊娠不良结局的受试者工作特征(ROC)曲线下面积(AUC)为0.835、0.711、0.774,联合预测的AUC为0.908(P<0.001),且外周血PLGF、NEFA、Hcy水平联合预测的AUC显著较单一指标高(P<0.05)。结论HDCP患者外周血PLGF、NEFA、Hcy水平异常表达,其水平与病情程度及预后预测有关,同时检测三者水平有助于提高预后预测效能,可为临床后续决策提供参考。

Objective To investigate the significance of nonestesterified fatty acid(NEFA),placental growth factor(PLGF)and homocysteine(Hcy)levels in patients with hypertensive disorder complicating pregnancy(HDCP).Methods A total of 200 HDCP patients admitted to Hainan Modern Women and Children′s Hospital from June 2019 to June 2022 were selected as the observation group,and 60 healthy pregnant women during the same period were selected as the control group.The levels of PLGF,NEFA and Hcy in peripheral blood of the two groups were detected and compared.Results PLGF in peripheral blood of observation group was lower than that of control group,NEFA and Hcy were higher than that of control group(P<0.05).The level of PLGF in peripheral blood was negatively correlated with the severity of HDCP,and the level of NEFA and Hcy in peripheral blood was positively correlated with the severity of HDCP(P<0.05).The area under the receiver operator characteristic curve(AUC)of peripheral blood PLGF,NEFA and Hcy levels in predicting adverse pregnancy outcomes in HDCP patients was 0.835,0.711 and 0.774,and the combined AUC was 0.908(P<0.001).The AUC predicted by PLGF,NEFA and Hcy levels in peripheral blood was significantly higher than that of single index(P<0.05).Conclusions The abnormal expression of PLGF,NEFA and Hcy levels in peripheral blood of HDCP patients is related to the severity of the disease and prognosis prediction.The detection of the three levels at the same time is helpful to improve the prognosis prediction efficiency,and can provide reference for clinical follow⁃up decision⁃making.