小檗碱抗泌尿系统肿瘤药理作用及其机制的研究进展

Research Progress in Pharmacological Effects of Berberine against Urological Tumors and Its Mechanisms

小檗碱临床上主要用于治疗肠道感染,但它其实有着广泛的药理作用,如抗炎、心脏保护、降血糖、调血脂、免疫调节等。此外,动物和细胞实验还显示,小檗碱对肺癌、肝癌、食管癌、结肠癌、宫颈癌、乳腺癌、膀胱癌、前列腺癌、淋巴瘤、黑色素瘤等各类型肿瘤亦有良好的药理作用。在本文中笔者主要就对小檗碱抗膀胱癌、肾细胞癌、前列腺癌等泌尿系统肿瘤的作用及其机制进行了综述,并对相关研究进展进行了分析。

Though berberine is mainly used for the clinical treatment of intestinal infections,it actually features a wide range of pharmacological effects,such as anti-inflammation,cardioprotection,hypoglycemic effect,blood lipid regulation,and immunomodulation.In addition,animal and cellular experiments also reveal that berberine exhibits favorable pharmacological effects on various types of tumors,such as lung cancer,liver cancer,esophageal cancer,colon cancer,cervical cancer,breast cancer,bladder cancer,prostate cancer,lymphoma and melanoma.This article mainly reviews the role of berberine against bladder cancer,renal cell carcinoma,prostate cancer and other urological tumors and its mechanisms,and analyzes the related research progress.