养正合剂在消化道肿瘤放化疗后厌食患者中的应用效果

Application effect of Yangzheng Mixture in patients with anorexia after radiotherapy and chemotherapy for gastrointestinal tumors

目的 探究消化道肿瘤放化疗后厌食患者应用养正合剂的治疗疗效。方法 对2016年7月~2018年7月期间收治183例消化道肿瘤放化疗后厌食患者资料予以回顾性分析,依据患者厌食改善方式将患者分别纳入对照组(n=89,化疗方案基础上接受康艾注射液)与研究组(n=94,对照组基础上接受养正合剂)。比较两组患者治疗前后中医证候积分,治疗效果,治疗前后红细胞免疫状态、胃肠激素指标、营养状态,预后情况。结果 两组患者治疗后食量减少、纳呆厌食、面色萎黄、形体偏瘦、精神欠振等中医证候积分较治疗前均明显改善,治疗后研究组患者上述中医证候积分均显著低于对照组,差异有统计学意义(P <0.05)。研究组患者治疗总有效率(95.74%)显著高于对照组(85.39%),差异有统计学意义(P <0.05)。两组患者治疗后红细胞免疫指标免疫黏附促进因子(FEER)水平较治疗前明显升高,免疫黏附抑制因子(FEIR)、红细胞免疫复合物受体花环率(RBC-ICR)水平较治疗前明显降低;研究组患者治疗后FEER水平高于对照组,FEIR、RBC-ICR水平低于对照组,差异有统计学意义(P <0.05)。两组患者治疗后肠胃激素指标胃动素(MTL)、生长抑素(SS)水平显著下降,研究组患者治疗后MTL、SS水平低于对照组,差异有统计学意义(P <0.05)。两组患者治疗后营养指数(PNI)及血红蛋白(HGB)、转铁蛋白(TF)水平明显高于治疗前,研究组患者PNI、HGB、TF水平均高于对照组,差异有统计学意义(P <0.05)。研究组患者6个月死亡率与1年死亡率低于对照组,仅1年死亡率比较差异有统计学意义(P <0.05)。结论 消化道肿瘤放化疗后厌食患者接受养正合剂治疗可以显著改善患者体内红细胞免疫状态及胃肠功能,改善患者营养状态。

Objective To investigate the clinical effect of Yangzheng Mixture in patients with anorexia after radiotherapy and chemotherapy for gastrointestinal tumors.Methods The data of 183 patients who developed anorexia after undergoing radiotherapy and chemotherapy for gastrointestinal tumors in the hospital from July 2016 and July 2018 were analyzed retrospectively.According to the improvement method of anorexia,the patients were divided into the control group(n=89,treatment with Kang’ai injection on the basis of chemotherapy)and the study group(n=94,treatment with Yangzheng Mixture on the basis of the treatment of control group).TCM syndrome scores,therapeutic effects,red blood cell immune status,gastrointestinal hormone indicators,nutritional status,and the prognosis were compared between the two groups.Results After treatment,the TCM syndrome scores for reduced food intake,anorexia,sallow complexion,lean body mass,and poor mental health in the two groups were significantly improved,and these TCM syndrome scores in the study group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).The total treatment response rate in the study group(95.74%)was significantly higher than that in the control group(85.39%),the difference was statistically significant(P<0.05).After treatment,the level of immune adhesion promotion factor(FEER)was significantly increased,and the levels of immune adhesion inhibitor(FEIR)and immune complex rosette(RBC-ICR)were significantly decreased in the two groups,after treatment,FEER level was higher,and FEIR and RBC-ICR level were lower in the study group than in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of motilin(MTL)and somatostatin(SS)in the two groups were significantly decreased,and the levels in the study group were lower than those in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of prognostic nutritional index(PNI),hemoglobin(HGB)and transferrin(TF)in the two groups were significantly increased,and the levels in the study group were higher than those in the control group,the difference was statistically significant(P<0.05).The 6-month and 1-year mortality rates in the study group were lower than those in the control group,but there only was a significant difference in 1-year mortality rate between the two groups(P<0.05).Conclusion Treatment with Yangzheng Mixture for patients with anorexia after radiotherapy and chemotherapy of gastrointestinal tumors can significantly improve the patients’erythrocyte immune status and gastrointestinal function,and improve their nutritional status.