眼睑刷上皮病变与干眼相关的研究进展

Research progress on the relationship between lid-wiper epitheliopathy and dry eye

眼睑刷上皮病变(LWE)指睑缘皮肤黏膜交界处区域之后的边缘处睑结膜出现相应的病理改变,在使用荧光素钠或丽丝胺绿等染色剂后出现染色。目前研究认为LWE形成主要是由于眼睑刷区域与眼面之间的摩擦增加所致,但具体机制尚不明确。LWE常见病因包括配戴角膜接触镜、泪膜异常、瞬目异常、炎症。临床研究发现,LWE可在常规干眼指标阴性时出现,所以LWE的诊断对干眼的早诊早治具有重要作用。然而,临床上关于LWE与干眼等指标相关的研究较少,本文结合国内外现有研究,对LWE的病因、发病机制、临床表现及治疗进行介绍,并总结LWE与干眼相关的研究进展,以期为深入研究LWE的病因及LWE在临床的应用提供参考。

Lid-wiper epitheliopathy(LWE)refers to the corresponding pathological changes in the palpebral conjunctiva after the skin-mucosa junction area of the palpebral margin,and staining occurs after using dyes such as fluorescein sodium or lissamine green.Current studies suggest that LWE mainly results from the increase of friction between the lid wiper and the ocular surface.The specific mechanism of LWE is not clear,but the common causes include wearing contact lenses,abnormal tear film,blink abnormalities and inflammation.Clinical studies have found that LWE appears when the conventional dry eye index is negative,so the diagnosis of LWE plays an important role in the early diagnosis and treatment of dry eye.However,there are few studies on the correlation between LWE and dry eye in clinical practice.Based on the existing clinical studies,the etiology,pathogenesis,clinical manifestations and treatment of LWE are introduced,and the research progress of LWE and dry eye is reviewed,hoping to provide reference for further investigation and the clinical application of LWE.