焦磷酸根离子化学传感器的研究进展

Research on pyrophosphate ion chemical sensor

离子广泛存在于自然界,在生物、医药、化学和环境科学等领域均起着重要作用。焦磷酸根离子(P_(2)O_(7)^(4-),缩写为PPi)参与人体内遗传物质DNA的复制和供能物质三磷酸腺苷(ATP)的合成,其含量的高低与一些疾病(比如癌症)的进展密切相关。实时选择性识别与检测PPi对生命活动的观测、疾病的诊断与生态环境的监测均具有重要的意义。因此,基于主客体化学的PPi离子高选择性化学传感器的设计与合成引起了人们的广泛关注,已成为超分子化学研究的热门领域。本文综述了近几年用于识别与检测PPi的化学传感器的研究进展,分析了其优势及不足,并对其应用前景进行了展望。

lons are widely found in nature and play important roles in biology,medicine,chemistry and environmental science.Pyro-phosphate ion(P_(2)O_(7)^(4-),abbreviated as PPi)is involved in the replication of the genetic material DNA and the synthesis of the ener-gy-supplying substance adenosine triphosphate(ATP)in the human body.It has been reported that the level of PPi is closely related to cancer progression.Real-time selective identification and detection of PPi is of great significance for the observation of life activi-ties,diagnosis of diseases and monitoring of ecological environment.Therefore,the design and synthesis of highly selective chemical sensor for PPi ion based on host-guest chemistry has attracted much attention and has become a popular field of supramolecular chemistry research.In this paper,we focued on the recent research progress of PPi ion chemical sensor,summarized their advantages and disadvantages,and its future perspectives were presented.