槲皮素锑的合成、表征及生物活性研究

Study on the Synthesis,Characterization and Biological Activity of Sb(III)Quercetin Complex

合成槲皮素锑并测定抗氧化活性。槲皮素与三氯化锑在76℃,pH=8.5,回流6 h可得槲皮素锑配合物。UV:带I从375 nm移到391 nm,红移了16 nm。带II从255 nm移到265 nm,红移了10 nm。IR:槲皮素锑羟基吸收峰变宽,强度减弱,υ(C=O)=1651.57 cm^(-1),红移了12 cm^(-1),苯环的特征吸收峰基本没变,在高场出现了638.29 cm^(-1)的吸收峰,可能是金属配位键υ(Sb-O)伸缩振动峰。^(1)H-NMR:3羟基上的氢消失。热分析显示槲皮素锑是有两个槲皮素配体与一个锑离子配位形成的。DPPH法显示,槲皮素锑清除自由基的能力下降。

The quercetin antimony is synthesized and its antioxidant activity is determined.The quercetin antimony can be obtained by the refluxing of quercetin and antimony trichloride at 76℃,pH=8.5 for 6h.UV-vis:band I shifts from 375 nm to 391 nm with a red shift of 16 nm.The band II shifts from 255 nm to 265 nm with a red shift of 10 nm.IR:the absorption peaks of quercetin antimony are broadened and the intensity decreases,υ(C=O)=1651.57 cm^(-1),the red shift is 12 cm^(-1),the characteristic absorption peak of benzene ring is almost unchanged,and the absorption peak appears at 638.29 cm^(-1 )may be the metal coordination bondυ(Sb-O)stretching vibration peak.^(1)H-NMR:the hydrogen on 3 hydroxyl disappears.The thermal analysis shows that the quercetin antimony is formed by two quercetin ligands coordinating with an antimony ion.DPPH method shows that the ability of scavenging free radicals of quercetin antimony declines compared with that of quercetin.