内镜在胃肠道移植物抗宿主病诊断中的应用进展

Progress on application of endoscopic diagnosis in gastrointestinal graft-versus-host disease

异基因造血干细胞移植(allogenic hematopoietic stem cell transplantation, allo-HSCT)是目前治愈恶性血液病的最有效、最根本的方法, 胃肠道移植物抗宿主病是移植后常见并发症, 其发病率高、临床表现重、胃肠道表现复杂、预后不佳, 需要尽早诊断和治疗, 临床上常与感染、化疗药物不良反应等病因鉴别, 内镜表现以及通过内镜获得病理是诊断胃肠道移植物抗宿主病的重要证据, 尤其是临床诊断困难者。该文就内镜在胃肠道移植物抗宿主病诊断中的意义、表现、活检部位和病理特征研究进展作一综述。

Allogenic hematopoietic stem cell transplantation is the most effective and fundamental method to cure malignant blood diseases at present.Gastrointestinal graft-versus-host disease is a common complication after transplantation.It requires early diagnosis and treatment,because of its high incidence rate,severe clinical manifestations,complex gastrointestinal manifestations and poor prognosis.In clinical practice,it is often differentiated from causes such as infection and chemotherapy drugs.Endoscopic manifestations and pathological findings obtained through endoscopy are important evidence for the diagnosis of gastrointestinal graft-versus-host disease,especially for gastrointestinal graft-versus-host disease that is difficult to be diagnosed clinically.This article reviews the significance,manifestations,biopsy sites,and pathological features of endoscopy in the diagnosis of gastrointestinal graft-versus-host disease.