呼吸道病毒致儿童塑型性支气管炎发病机制的研究进展

Progress on the pathogenesis of plastic bronchitis caused by respiratory viruses in children

塑型性支气管炎(plastic bronchitis,PB)好发于2~12岁儿童,是一类少见的急性重症呼吸道疾病。PB的病因包括心脏性疾病、遗传性血红蛋白分子功能紊乱疾病、肺部疾病、淋巴系统疾病等,其中肺部疾病以感染相关性疾病常见。目前,国内报道病例多为感染后的PB,其临床表现形式多样,严重程度不一,发病机制目前尚不明确。现有研究认为,PB的发病机制与气道存在感染、炎症反应、免疫功能异常等原因相关。该文综述了呼吸道病毒致儿童塑型性支气管炎发病机制的研究进展,以期提高临床医生对PB的认识。

Plastic bronchitis(PB)is a rare acute severe respiratory disease in children aged 2-12 years old.The causes of PB include heart disease,hereditary hemoglobin molecule dysfunction disease,lung disease,lymphatic system disease,etc.Among them,lung disease is commonly associated with infection.At present,most of the reported cases in China are post infection PB,with diverse clinical manifestations and varying degrees of severity.The pathogenesis is currently unclear.Existing research suggests that the pathogenesis of PB is related to airway infections,inflammatory reactions,and immune dysfunction.This article reviews the research progress on the pathogenesis of respiratory virus induced PB in children,with the aim of improving clinical doctors′understanding of PB.