长航人员肠道微生态平衡与疾病相关性研究进展

Relationship between intestinal microecological balance and diseases during long voyage:research progress

肠道菌群与宿主共同进化,在维持机体免疫稳态中发挥重要作用。肠道菌群可以直接或通过代谢产物间接参与多种疾病的发生、发展。研究人员根据肠道微生态与其他脏器间的相互关联,提出了“肠-脑轴”“肠-肺轴”等学说,并在基础和临床研究领域进行了广泛验证。长航人员容易发生肠道菌群紊乱,也经常出现其他健康问题。现阶段需积极开展相关研究,明确长航人员肠道菌群紊乱与健康状态的关系,探索合理的干预措施,以维护肠道微生态平衡,提高长航人员生活质量、预防疾病发生。

Intestinalflora coevolutes with the host and plays an important role in maintaining immune homeostasis.It participates in the development and progression of a variety of diseases,directly or indirectly through metabolites.Researchers have proposed the theories of the“gut-brain axis”and“gut-lung axis”based on the interrelationship between intestinal microecology and other organs.These theories have been widely verified in basic and clinical research fields.Long voyage personnel are prone to intestinal flora disorder and often suffer from other health problems.At present,studies should be actively carried out to clarify the relationship between intestinalflora disorder and health status of long voyage personnel and explore reasonable intervention measures to maintain intestinal microecological balance,improving the quality of life and preventing diseases among them.