胆管癌相关炎症分子机制的研究进展

Advances in the molecular mechanisms of inflammation associated with cholangiocarcinoma

胆管系统的炎性疾病可能是胆管癌的危险因素。迄今为止,与慢性炎症相关的疾病,诸如肝内胆管结石、原发性硬化性胆管炎、Caroli病和吸虫感染等胆管癌(CCA)的前驱疾病研究较多,并且与CCA发生发展密切相关,也因此慢性炎症被认为是胆道良性疾病恶变的关键。因而,研究胆管炎症疾病的分子机制,有助于探索炎性因素导致胆管上皮细胞恶变向CCA的原因,为治疗CCA提供新的方向。本文结合近年来炎性因素导致胆道良性疾病向CCA恶变的研究进展,基于炎症相关分子机制在CCA发生发展中发挥的作用作一综述。

Inflammatory diseases of the biliary system may be a risk factor for cholangiocarcinoma(CCA).Thus far,research on precursor diseases related to chronic inflammation,such as intrahepatic bile duct stones,primary sclerosing cholangitis,Caroli’s disease,and parasitic infections,has been more prevalent and closely associated with the occurrence and development of CCA.Therefore,chronic inflammation is considered a key factor in the malignant transformation of benign biliary diseases.Studying the molecular mechanisms of biliary inflammatory diseases can help explore the reasons why inflammatory factors lead to the malignant transformation of biliary epithelial cells into CCA,and provide new directions for the treatment of CCA.This article provides a review of recent research on the malignant transformation of benign biliary diseases into CCA caused by inflammatory factors,based on the role played by inflammation-related molecular mechanisms in the occurrence and development of CCA.