探讨米非司酮联合甲氨蝶呤不同方案治疗异位妊娠的临床疗效及对肝功能与血液流变学的影响

To explore the clinical efficacy of different regimens of mifepristone combined with methotrexate in the treatment of Ectopic pregnancy and its influence on liver function and Hemorheology

目的探讨米非司酮联合甲氨蝶呤不同方案治疗异位妊娠的临床疗效及对肝功能与血液流变学的影响。方法选取2019年11月-2021年11月廉江市妇幼保健院收治的120例异位妊娠患者作为研究对象,根据血清β-hCG值分为对照组(n=60)和观察组(n=60),对照组应用米非司酮联合甲氨蝶呤连续肌肉注射治疗,观察组应用米非司酮联合甲氨蝶呤单次肌内注射治疗。结果观察组临床疗效高于对照组(P<0.05);观察组ALT及AST值与对照组比较,无统计学意义(P>0.05);观察组纤维蛋白原、血浆黏稠度及全血黏稠度低于对照组(P<0.05)。结论米非司酮联合甲氨蝶呤不同方案治疗异位妊娠能够取得理想的效果,对患者的肝功能影响不大,能够改善血液流变学,值得应用。

Objective To investigate the clinical efficacy of different regimens of mifepristone combined with methotrexate in the treatment of Ectopic pregnancy and the effect on liver function and Hemorheology.Methods Selecting 120 patients with ectopic pregnancy admitted to our hospital from November 2019 to November 2021,based on the serumβ-hCG values were divided into a control group(n=60)and an observation group(n=60).The control group received continuous intramuscular injection of mifepristone combined with methotrexate,while the observation group received single intramuscular injection of mifepristone combined with methotrexate.Result The clinical efficacy of the observation group was higher than that of the control group(P<0.05);there was no statistically significant difference in ALT and AST values between the observation group and the control group(P>0.05);the fibrinogen,plasma viscosity,and whole blood viscosity in the observation group were lower than those in the control group(P<0.05).Conclusion Different regimens of mifepristone combined with methotrexate in the treatment of ectopic pregnancy can achieve ideal results,with little impact on the patient's liver function,and can improve hemorheology,which is worthy of application.