Sonazoid超声造影在肾透明细胞癌诊断中的可行性研究

The feasibility study of Sonazoid contrast-enhanced ultrasound in the diagnosis of renal clear cell carcinoma

目的 对比分析肾透明细胞癌Sonazoid超声造影与SonoVue超声造影、增强CT增强特征,探讨Sonazoid超声造影在肾透明细胞癌诊断中的可行性。方法 选取我院经穿刺活检或手术病理证实的47例肾透明细胞癌患者(共47个病灶),均行超声造影和增强CT检查,其中采用SonoVue进行超声造影的患者21例(SonoVue-CEUS组),采用Sonazoid进行超声造影的患者26例(Sonazoid-CEUS组),比较两组病灶超声造影、增强CT增强特征。结果 SonazoidCEUS组与SonoVue-CEUS组在病灶增强方式、消退方式、峰值强度及达峰时增强均匀性方面比较差异均无统计学意义。Sonazoid-CEUS组超声造影与增强CT峰值强度均以富血供表现为主(80.77%、84.62%),增强及消退方式均以快进快退表现为主(73.08%、69.23%),二者比较差异均无统计学意义;超声造影示病灶达峰时均匀增强占比显著高于增强CT(26.92%vs. 3.85%),差异有统计学意义(P<0.05)。结论 Sonazoid同样适用于肾脏超声造影,与SonoVue超声造影及增强CT一样均可较好地显示肾透明细胞癌的血流灌注特征。

Objective To compare and analyze the contrast-enhanced ultrasound(CEUS)features of Sonazoid,SonoVue and contrast-enhanced CT in renal clear cell carcinoma,and to explore the feasibility of Sonazoid CEUS in the diagnosis of renal clear cell carcinoma.Methods Forty-seven patients with renal clear cell carcinoma(47 lesions)confirmed by surgery or puncture pathology in our hospital were selected for CEUS and contrast-enhanced CT examination.According to the different types of ultrasound contrast agents,the patients were divided into SonoVue-CEUS group(21 cases)and Sonazoid-CEUS group(26 cases).The enhancement features of CEUS and contrast-enhanced CT were compared.Results There were no significant differences in lesion enhancement pattern,washout pattern,peak intensity and the homogeneity of enhancement at the peak between Sonazoid-CEUS group and SonoVue-CEUS group.In Sonazoid-CEUS group,both CEUS and contrast-enhanced CT primarily demonstrated a rich blood supply(80.77%,84.62%),and a predominant fast-in and fast-out washout pattern(73.08%,69.23%).The differences between the two groups were not statistically significant.Sonazoid-CEUS showed a significantly higher proportion of lesions with homogeneous enhancement at the peak compared with contrast-enhanced CT(26.92%vs.3.85%),and the difference was statistically significant(P<0.05).Conclusion Sonazoid is equally suitable for kidney CEUS,and can better display the blood perfusion characteristics of renal clear cell carcinoma like SonoVue-CEUS and contrast-enhanced CT.