当归紫草膏外用治疗血热生风型糖尿病皮肤瘙痒症的疗效观察

Therapeutic effects of Danggui Zicao ointment on diabetic pruritus caused by heat and wind in blood

目的观察当归紫草膏外用治疗血热生风型糖尿病皮肤瘙痒症的临床疗效。方法选取金华市中医医院2020年11月至2022年3月收治的血热生风型糖尿病皮肤瘙痒症患者197例,采用随机数字表法分为对照组(n=99)和观察组(n=98),进行随机对照研究。两组均予基础降血糖治疗,对照组口服盐酸左西替利嗪片,观察组在对照组基础上外用当归紫草膏,疗程4周。比较两组治疗前后12项目瘙痒严重程度量表(12-PSS)评分及临床疗效。结果治疗4周后,两组12-PSS评分均较治疗前下降(t=18.09、11.31,均P<0.05),观察组12-PSS评分为(7.72±1.64)分,低于对照组的(9.35±2.18)分,组间差异有统计学意义(t=3.52,P<0.05)。观察组总有效率为87.8%(86/98),高于对照组的76.8%(76/98),组间差异有统计学意义(χ^(2)=4.06,P<0.05)。结论当归紫草膏外用可有效改善血热生风型糖尿病皮肤瘙痒症患者的临床症状,提高患者生活质量,具有临床推广价值。

Objective To investigate the clinical efficacy of Danggui Zicao ointment on diabetic pruritus caused by heat and wind in blood.Methods A total of 197 patients with diabetic pruritus caused by heat and wind in blood who received treatment in Jinhua Hospital of Traditional Chinese Medicine from November 2020 to March 2022 were included in this randomized controlled study.They were randomly divided into a control group(n=99)and an observation group(n=98).Based on basic hypoglycemic treatment,the control group was given oral levocetirizine hydrochloride tablets,while the observation group was externally given Danggui Zicao ointment.Both groups were treated for 4 successive weeks.Pre-and post-treatment 12-Item Pruritus Severity Scale(12-PSS)score and clinical efficacy were compared between the two groups.Results After 4 weeks of treatment,the 12-PSS score in each group significantly decreased compared with that before treatment(t=18.09,11.31,both P<0.05).The 12-PSS score in the observation group was(7.72±1.64)points,which was significantly lower than(9.35±2.18)points in the control group(t=3.52,P<0.05).The total effective rate in the observation group was 87.8%(86/98),which was significantly higher than 76.8%(76/98)in the control group(χ^(2)=4.06,P<0.05).Conclusion Danggui Zicao ointment can effectively improve the clinical symptoms of patients with diabetic pruritus caused by heat and wind in blood,improve quality of life,and deserves clinical promotion.