耳穴压豆联合艾司西酞普兰治疗抑郁症疗效观察

Clinical efficacy of ear acupoint pressing beans combined with escitalopram tablets in the treatment of depression

目的探讨耳穴压豆联合艾司西酞普兰治疗抑郁症的临床疗效。方法采用随机对照研究,选取2021年10月至2023年2月永康市第三人民医院精神科收治的抑郁症患者100例,按照随机数字表法分成对照组、观察组各50例。对照组予以艾司西酞普兰片治疗,观察组予以耳穴压豆联合艾司西酞普兰片治疗,两组治疗8周。观察两组汉密尔顿抑郁量表(HAMD)评分、中医证候积分、匹兹堡睡眠质量指数(PSQI)评分、5-羟色胺水平、临床疗效以及不良反应。结果治疗后,两组HAMD评分均降低(均P<0.001),且观察组[(15.89±1.08)分]低于对照组[(19.24±1.27)分](t=14.21,P<0.001);中医证候积分均降低(均P<0.001),且观察组[(6.83±1.24)分]低于对照组[(9.78±1.80)分](t=9.54,P<0.001);PSQI评分均降低(P<0.001),且观察组[(7.00±1.34)分]低于对照组[(9.48±1.82)分](t=7.76,P<0.001);两组治疗后5-羟色胺水平均升高(均P<0.001),且观察组[(40.65±5.37)μg/L]高于对照组[(32.52±4.20)μg/L](t=8.43,P<0.001)。观察组总有效率为94%(47/50),高于对照组的80%(40/50)(χ^(2)=4.33,P=0.037);观察组不良反应发生率为8%(4/50),对照组为10%(5/50),差异无统计学意义(χ^(2)=0.12,P=0.727)。结论耳穴压豆联合艾司西酞普兰治疗抑郁症的效果较好,可减轻患者症状,提高睡眠质量,改善5-羟色胺水平,且不良反应少,值得推广。

Objective To investigate the clinical efficacy of ear acupoint pressing beans combined with escitalopram tablets in the treatment of depression.Methods A total of 100 patients with depression who received treatment in the Department of Psychiatrics,The Third People's Hospital of Yongkang from October 2021 to February 2023 were included in this randomized controlled study.These patients were randomly divided into a control group and an observation group,with 50 patients in each group,using a random number table method.The control group was treated with escitalopram tablets,while the observation group was treated with ear acupoint pressing beans combined with escitalopram tablets.The two groups were treated for 8 weeks.Hamilton Depression Scale(HAMD),traditional Chinese medicine syndrome scores,Pittsburgh Sleep Quality Index(PSQI),serotonin levels,clinical efficacy,and adverse reactions were recorded in each group.Results After treatment,the HAMD scores in each group were significantly decreased compared with those before treatment(both P<0.001).After treatment,the HAMD scores in the observation group were significantly lower than those in the control group[(15.89±1.08)points vs.(19.24±1.27)points,t=14.21,P<0.001].After treatment,the traditional Chinese medicine syndrome scores in each group were significantly lower than those before treatment(both P<0.001).After treatment,the traditional Chinese medicine syndrome scores in the observation group were significantly lower than those in the control group[(6.83±1.24)points vs.(9.78±1.80)points,t=9.54,P<0.001].After treatment,the PSQI scores in each group were significantly decreased compared with those before treatment(both P<0.001).After treatment,the PSQI scores in the observation group were significantly lower than those in the control group[(7.00±1.34)points vs.(9.48±1.82)points,t=7.76,P<0.001].After treatment,the levels of serotonin in each group were significantly decreased compared with those before treatment(both P<0.001).The levels of serotonin in the observation group were significantly higher than those in the control group[(40.65±5.37)μg/L vs.(32.52±4.20)μg/L,t=8.43,P<0.001].The total effective rate in the observation group was significantly higher than that in the control group[94%(47/50)vs.80%(40/50),χ^(2)=4.33,P=0.037].The incidence of adverse reactions in the observation group was significantly lower than that in the control group[8%(4/50)vs.10%(5/50),χ^(2)=0.12,P=0.727].Conclusion The combination of ear acupoint pressing beans and escitalopram tablets shows good clinical efficacy in the treatment of depression.This combined therapy can reduce symptoms,improve sleep quality,increase serotonin levels and also has fewer adverse reactions,making it a worthy candidate for clinical promotion.