摘要
心肌梗死是冠状动脉急性闭塞引起的严重而持久的缺血性心肌坏死,传统药物治疗靶向性较差,到达损伤区域的药物剂量不足且停留时间偏短。近年来研究显示,纳米药物实现了对病变组织的选择性靶向输送,在心肌梗死的靶向治疗中,借助其独特的理化性质,纳米载体可携带炎症因子受体、炎症信号通路抑制剂、抗氧化剂、治疗基因、特异性抗体和生长因子等到达心肌组织释放药物。纳米药物通过中和炎症因子、抑制炎症信号通路和炎症基因表达、调节巨噬细胞表型等对抗单核巨噬细胞及中性粒细胞介导的炎症损伤;通过抗氧化剂消除过氧化物的方式对抗氧化应激性损伤;通过生长因子促进心肌组织的再生和修复;通过水凝胶修复心脏电传导功能并促进心脏间充质干细胞的增殖分化。研究发现,纳米药物可保护缺血心肌组织,改善心脏功能。本文对纳米药物在心肌梗死治疗中的应用研究进展进行综述。
Myocardial infarction is a severe and persistent ischemic myocardial necrosis caused by acute occlusion of the coronary artery.Traditional drugs have poor targeting for the treatment of myo-cardial infarction,resulting in insufficient dosages of drugs that can reach the injured area and shorter drug residence time.In recent years,research has shown that nanodrugs have achieved selective targeted delivery to diseased tissues.In the targeted treatment of myocardial infarction,nanodrugs utilize the unique physicochemical properties of nanocarriers to carry inflammatory factor receptors,inhibitors of inflammatory signaling pathways,antioxidants,therapeutic genes,specific antibodies and growth factors to the myocardial tissue to release drugs.Nanodrugs counteract inflammatory damage mediated by monocytes,macrophages,and neutrophils by neutralizing inflammatory factors,inhibiting inflammatory signaling pathways and inflammatory gene expression,and regulating macrophage phenotype.Antioxi-dant irritability injury can be prevented by eliminating peroxide with antioxidant.The regeneration and repair of myocardial tissue can be promoted via growth factors.Nanodrugs can repair the cardiac elec-tric conduction function and promote the proliferation and differentiation of cardiac mesenchymal stem cells through hydrogel.Research has found that nanodrugs can protect ischemic myocardial tissue and improve cardiac function.This article provides a review of the research progress in the applications of nanodrugs in the treatment of myocardial infarction.
作者
张敏娜
钟鸣
王光辉
ZHANG Minna;ZHONG Ming;WANG Guanghui(College of Pharmacy,Jining Medical University,Rizhao 276826,China;Rizhao Elderly University,Rizhao 276826,China;Forensic Center of Jining Medical University,Jining 272013,China)
出处
《中国药理学与毒理学杂志》
CAS
北大核心
2023年第11期861-871,共11页
Chinese Journal of Pharmacology and Toxicology
基金
山东省自然科学基金项目(ZR2014HM038)
山东省中医药科技发展计划项目(20190453)。
关键词
心肌梗死
纳米药物
炎症
基因
myocardial infarction
nanodrugs
inflammation
genes