肺炎支原体检出率与哮喘患儿临床结局和生存质量的相关性研究

To investigate the impact of respiratory mycoplasma detection rate onclinical prognosis and quali⁃ty of life in children with asthma

目的探讨肺炎支原体检出率与哮喘患儿临床预后和生存质量(QOL)的相关性研究。方法选取2020年1月至2021年1月于门诊儿科收治的120例支气管哮喘患者作为研究对象,随访12个月,每2个月随访一次,分析肺炎支原体(MP)阳性率与药物指数、哮喘严重指数、哮喘控制问卷(ACQ)评分、小儿哮喘照护生命质量问卷(PACQLQ)评分、年龄和机体免疫力的相关性。结果平均每人随访(3.98±1.05)次,其中75例完成5次随访,38例完成2~4次随访,5例完成2次随访;共有70例患儿MP培养阳性,其中5月和8月阳性率最高;入组后患儿不同随访时间哮喘严重指数及PACQLQ无明显变化(P>0.05),但采用Pearson相关分析表明各时间点的哮喘严重指数与PACQLQ均成负相关(P<0.05);MP阳性和阴性访视期间哮喘药物指数、严重指数、ACQ、PACQLQ组间比较,差异无统计学意义(P>0.05);随访期间,<3岁的哮喘患儿MP的阳性率最低,>6岁的哮喘患儿MP阳性率最高,不同年龄阶段哮喘患儿的MP阳性率有统计学差异(P<0.05)。结论随着年龄增高,支气管哮喘患儿MP阳性率增加,但MP阳性不影响患儿预后、生存质量。

Objective To investigate the correlation between the detection rate of Mycoplasma pneumoniae and the clin⁃ical prognosis and quality of life(QOL)of asthmatic children.Methods 120 patients with bronchial asthma who were trea⁃ted in outpatient pediatrics from January 2020 to January 2021were selected as the research subjects,followed up for 12 months and followed up every 2 months to analyze the positive rate of Mycoplasma pneumonia(MP)and drug index,asthma Correlation between severity index,asthma control questionnaire(ACQ)score,pediatric asthma care quality of life question⁃naire(PACQLQ)score,age and body immunity.Results Follow⁃up(3.98±1.05)times per person,of which 75 patients completed 5 follow⁃ups,38 patients completed 2 to 4 follow⁃ups,and 5 patients completed 2 follow⁃ups;a total of 70 children had positive MP cultures,of which May and August The positive rate was the highest;there was no significant change in asthma severity index and PACQLQ at different follow⁃up times(P>0.05),but the Pearson correlation analysis showed that the asthma severity index and PACQLQ were negatively correlated at each time point(P<0.05).There was no significant difference in asthma drug index,severity index,ACQ and PACQLQ between MP positive and negative groups(P>0.05).During the follow⁃up,children with asthma less than 3 years old had the lowest MP positive rate,and those with asthma 6 years old The MP positive rate was highest in children,and the MP positive rate in children with asthma at different ages was significantly different(P<0.05).Conclusion With the increase of age,the MP positive rate of children with bronchial asthma increases,but MP positive does not affect the prognosis and quality of life of children.