银翘散合竹叶石膏汤联合抗生素降阶梯疗法治疗重症肺炎的疗效观察

Effect of Yinqiao San Combined with Lophatherum and Gypsum Decoction and Antibiotic De⁃es⁃calation Therapy in the Treatment of Severe Pneumonia

目的研究银翘散合竹叶石膏汤联合抗生素降阶梯疗法治疗重症肺炎的疗效。方法选取2019年4月~2021年2月我院90例重症肺炎患者,采用随机数字表法分为对照组与研究组,各45例。两组常规治疗后,对照组实施抗生素降阶梯疗法,研究组在抗生素治疗基础上联合银翘散合竹叶石膏汤进行加减治疗。比较两组治疗后疗效、呼吸功能与炎症因子水平。结果研究组有效率91.11%高于对照组75.56%(P<0.05)。治疗后研究组呼吸做功低于对照组,氧合指数、动态顺应性高于对照组(P<0.05)。治疗后两组CRP、IL⁃6水平显著下降(P<0.05),且研究组CRP、IL⁃6水平低于对照组(P<0.05)。结论银翘散合竹叶石膏汤联合抗生素降阶梯疗法能有效缓解重症肺炎患者症状体征,提高其有效率,改善呼吸功能并减轻机体炎症反应,促进病情好转,可作为临床首选治疗方法之一。

Objective To investigate the effect of Yinqiao San combined with lophatherum and gypsum decoction and antibiotic de⁃escalation therapy in the treatment of severe pneumonia.Methods Ninety patients with severe pneumonia in our hospital from April 2019 to February 2021 were enrolled,and divided into two groups by random number table methods,each with 45 cases.Control group received antibiotic de⁃escalation therapy,while study group received Yinqiao San com⁃bined with lophatherum and gypsum decoction and antibiotic de⁃escalation therapy.Then the clinical efficacy,respiratory function and inflammatory factors were compared between groups.Results The clinical efficacy of study group was signifi⁃cantly higher than that of control group(91.11%vs 75.56%,P<0.05).Compared with control group,study group had lower work of breathing,and higher oxygenation index and dynamic compliance(all P<0.05).After treatment,there was a decrease in levels of CRP and IL⁃6,and the decrease was more significant in study group than in control group(P<0.05).Conclusion Application of Yinqiao San combined with lophatherum and gypsum decoction and antibiotic de⁃escalation therapy in the treatment of severe pneumonia can effectively ameliorate the respiratory function,alleviate the inflammation,and promote the recovery,which is worthy of recommendation.