盐酸倍他司汀联合手法复位治疗良性阵发性位置性眩晕的效果

Effect of Betahistine Hydrochloride Combined with Manual Reduction on Benign Paroxysmal Positional Vertigo

目的:探讨盐酸倍他司汀联合手法复位治疗良性阵发性位置性眩晕(BPPV)的效果。方法:选取2019年10月—2022年11月谷城县中医院收治的BPPV患者96例为观察对象,根据随机数字表法分为对照组和观察组,各48例。对照组采取手法复位治疗,观察组采取盐酸倍他司汀联合手法复位治疗。比较两组患者残留症状缓解时间、眩晕障碍(DHI)评分、前庭症状指数(VSI)、平衡功能(BBS)评分、计时平衡试验、临床疗效、复发率和不良反应发生率。结果:观察组头晕、平衡障碍缓解时间短于对照组,差异有统计学意义(P<0.05);干预后,观察组DHI评分、VSI指数低于对照组,BBS评分高于对照组,计时平衡试验时间长于对照组,差异有统计学意义(P<0.001);观察组治疗总有效率高于对照组,差异有统计学意义(P=0.025);观察组复发率低于对照组,差异有统计学意义(P=0.027);两组均未发生严重不良反应。结论:盐酸倍他司汀联合手法复位治疗BPPV效果显著,可改善患者眩晕症状和平衡功能障碍,降低复发率,且不会增加不良反应,安全性较高。

Objective:To investigate the effect of betahistine hydrochloride combined with manual reduction on benign paroxysmal positional vertigo(BPPV).Methods:A total of ninety-six BPPV patients admitted to Gucheng County Hospital of Traditional Chinese Medicine from October 2019 to November 2022 were selected as the observation objects,and were divided into control group and observation group according to random number table method,with forty-eight cases in each group.The control group was treated with manual reduction,and the observation group was treated with betahistine hydrochloride combined with manual reduction.The residual symptom remission time,vertigo disorder(DHI)score,vestibular symptom index(VSI),balance function(BBS)score,timing balance test,clinical efficacy,recurrence rate and incidence of adverse reactions were compared between the two groups.Results:The remission time of dizziness and balance disorder in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05);After the intervention,the DHI score and VSI index of the observation group were lower than that of the control group,the BBS score was higher than that of the control group,and the timing balance test time was longer than that of the control group,the difference was statistically significant(P<0.001);The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.025);The recurrence rate of observation group was lower than that of control group,and the difference was statistically significant(P=0.027);No serious adverse reactions occurred in both groups.Conclusion:Betahistine hydrochloride combined with manual reduction in the treatment of BPPV is effective,can improve vertigo symptoms and balance dysfunction,reduce the recurrence rate,and does not increase adverse reactions,and has high safety.