肝功能指标在肝硬化疾病诊断中的应用价值分析

Analysis of the Application Value of Liver Function Indicators in the Diagnosis of Liver Cirrhosis Disease

目的:探究肝硬化疾病诊断中肝功能指标的应用价值。方法:选取2018年7月—2020年7月广州市番禺区第六人民医院收治的肝硬化患者60例为观察组,同时选取同时期健康体检者60例为对照组。观察组给予恩替卡韦治疗6个月,两组研究对象均进行生化指标检测,测定肝功能指标(总胆汁酸、血清白蛋白、血清胆碱酯酶、血清总胆固醇)。比较两组肝功能指标水平,不同肝功能分级患者与观察组治疗前及治疗1、3、6个月后的肝功能指标。结果:观察组总胆汁酸水平高于对照组,血清白蛋白、血清胆碱酯酶、血清总胆固醇水平低于对照组,差异有统计学意义(P<0.001)。B级、C级患者总胆汁酸水平低于A级,血清白蛋白、血清胆碱酯酶、血清总胆固醇水平高于A级,差异有统计学意义(P<0.05);A级、B级、C级患者总胆汁酸水平逐级降低,血清白蛋白、血清胆碱酯酶、血清总胆固醇水平逐级升高,差异有统计学意义(P<0.001)。治疗后1、3、6个月,总胆汁酸水平低于治疗前,血清白蛋白、血清胆碱酯酶、血清总胆固醇水平高于治疗前,差异有统计学意义(P<0.05);治疗前与治疗后1、3、6个月,观察组患者总胆汁酸逐渐降低,血清白蛋白、血清胆碱酯酶、血清总胆固醇水平逐渐升高,差异有统计学意义(P<0.05)。结论:肝硬化疾病诊断中应用肝功能指标检测,能够有效实现疾病诊断,了解患者肝功能分级,有助于判断临床疗效。

Objective:To investigate the application value of liver function indexes in the diagnosis of liver cirrhosis disease.Methods:Sixty cases of liver cirrhosis patients admitted to Guangzhou Panyu District Sixth People's Hospital from July 2018 to July 2020 were selected as the observation group,while sixty cases of healthy medical checkups in the same period were selected as the control group.The observation group was given entecavir treatment for 6 months,and both study groups were tested for biochemical indexes and liver function indexes(total bile acids,serum albumin,serum cholinesterase,serum total cholesterol)were measured.Comparison of the levels of liver function indexes between the two groups,patients with different liver function grades and the observation group before treatment and after 1,3 and 6 months of treatment.Results:The total bile acid level of the observation group was higher than that of the control group,and the levels of serum albumin,serum cholinesterase,and serum total cholesterol were lower than those of the control group,and the difference was statistically significant(P<0.05);The total bile acid level of grade B and C patients was lower than that of grade A,and the levels of serum albumin,serum cholinesterase,and serum total cholesterol were higher than that of grade A.The difference was statistically significant(P<0.001);The total bile acid level of grade A,B and C patients decreased step by step,and the serum albumin,serum cholinesterase and serum total cholesterol levels increased step by step,with statistically significant differences(P<0.001);At 1,3,and 6 months after treatment,total bile acid levels were lower than before treatment,and serum albumin,serum cholinesterase,and serum total cholesterol levels were higher than before treatment,with statistically significant differences(P<0.05);Before treatment and 1,3 and 6 months after treatment,total bile acids gradually decreased and serum albumin,serum cholinesterase and serum total cholesterol levels gradually increased in the observation group,with statistically significant differences(P<0.05).Conclusion:The application of liver function index test in the diagnosis of liver cirrhosis disease can effectively realize the diagnosis of the disease,understand the patient's liver function grading,and help to judge the clinical efficacy.