胃癌胃镜活检标本HER-2检测中国专家共识(2023版)

Consensus of Chinese experts on detection of HER-2 in gastroscopic biopsy specimens of gastric cancer(2023 edition)

胃癌是最常见的消化道恶性肿瘤之一。人表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)是胃癌(包括胃食管结合部腺癌)临床治疗的重要靶点。规范、准确的胃镜活检标本HER2表达状态检测对于胃癌分子分型与选择抗HER-2靶向药物治疗具有重要意义。本共识基于循证医学证据和国际通行的Delphi法,在胃镜活检标本HER-2检测的临床意义、适用人群、活检操作规范、标本前期处理、检测方法、检测质量控制与多学科合作等方面达成初步统一,以期对临床工作提供指导。

Gastric cancer is one of the most common malignant tumors of the digestive tract.Human epidermal growth factor receptor-2(HER-2)is an important target for clinical treatment of gastric cancer(including gastroesophageal junction adenocarcinoma).Standardized and accurate detection of HER-2 expression in gastroscopic biopsy specimens is vitally important for molecular typing of gastric cancer and selection of anti-HER-2 targeted drug therapy.Preliminary consensuses,based on medical evidence and the internationally accepted Delphi method,have been reached on the clinical significance,applicable population,biopsy operation specifications,specimen pretreatment,detection method,detection quality control,and multidisciplinary cooperation on the HER-2 detection of gastroscopic biopsy specimens.These consensuses will potentially provide guidance for clinical work.