环状RNA通过经典信号通路对系统性红斑狼疮影响的研究进展

Research progress of the impact of circular RNA on systemic lupus erythematosus through classical signaling pathways

系统性红斑狼疮(SLE)是一种由自身抗体介导的慢性自身免疫性疾病,累及皮肤、肾脏、神经系统、血液系统等,其发病机制涉及多个信号通路和免疫细胞的功能异常。研究发现环状RNA(circRNA)可以调节PI3K/Akt/mTOR、JAK/STAT、TLR、Wnt和Notch等信号通路,介导T、B淋巴细胞活化,从而影响SLE的发病。本文针对circRNA在这些通路中所发挥的作用及其与SLE发生发展可能的关联进行综述,以便我们更深入地理解circRNA在SLE中的作用机制,为疾病的诊断和治疗提供新的思路和目标。

Systemic lupus erythematosus(SLE)is a chronic autoimmune disease mediated by autoantibodies,and affects various organs including skin,kidney,nervous system and blood system.Its pathogenesis involves dysregulation of multiple signaling pathways and immune cells.Rresearches have demonstrated that circular RNA(circRNA)can modulate signaling pathways such as PI3K/Akt/mTOR,JAK/STAT,TLR,Wnt and Notch,and mediate the activation of T and B lymphocytes,thereby affecting the pathogenesis of SLE.This review focuses on the role of circular RNA in these pathways and its potential association with the occurrence and development of SLE,which is essential for gaining a comprehensive understanding of its pathogenesis as well as providing novel insights and targets for diagnosis and treatment of the disease.