生物治疗联合外科治疗克罗恩病肛周病变的策略和进展

Strategies and advances in the combined surgical management of perianal lesions in Crohn′s disease

瘘管型肛周克罗恩病(PFCD)的治疗仍然是炎性肠病中最大的挑战之一。尽管研发了一些新的治疗,例如引入生物疗法,包括最有前景的骨髓间充质干细胞领域,但仍然缺乏最有效的治愈的方法。外科手术仍然是PFCD的最主要方法,且每个治疗方案均根据不同患者采用的个性化治疗。内窥镜治疗技术的应用、经验丰富的外科医生、多学科的合作有望为患者带来更光明的未来。

Perianal fistulizing Crohn′s disease(PFCD)remains one of the greatest challenges in inflammatory bowel disease.Despite the development of new treatments,such as the introduction of newer biologics,including the most promising field of bone marrow mesenchymal stem cells,the most effective cure is still lacking.Surgery remains the predominant approach to PFCD and each treatment option is individualized according to the different patients.The endoscopic and surgical techniques,experienced surgeons,and multidisciplinary collaboration holds promisea brighter future for patients.