肠道菌群对动脉粥样硬化性心血管疾病发病影响的研究进展

Research progress of the effect of intestinal flora on the pathogenesis of atherosclerotic cardiovascular disease

动脉粥样硬化导致的动脉狭窄是心血管疾病中最常见的病因,除已知的危险因素外,研究人员发现肠道菌群可以通过其代谢产物(短链脂肪酸、氧化三甲胺、吲哚酸盐)、胆汁酸的代谢以及炎症反应影响动脉粥样硬化的发生,且相关证据已得到实验支持。文章通过对肠道菌群与动脉粥样硬化性心血管疾病之间的关系进行系统性回顾,介绍肠道菌群对动脉粥样硬化性心血管疾病发病影响的微观机制,以及近年来以肠道菌群为靶点对动脉粥样硬化性心血管疾病的治疗进展。

Artery stenosis due to atherosclerosis is the most common cause of cardiovascular disease.In addition to known risk factors,researchers have found that intestinal flora can influence the pathogenesis of atherosclerosis through its metabolites(short-chain fatty acids,trimethylamine oxide,indoles),the metabolism of bile acids,and the inflammatory response,and the relevant evidence has been supported experimentally.This article presents a systematic review of the relationship between intestinal flora and atherosclerotic cardiovascular disease,the microscopic mechanisms by which intestinal flora affect the pathogenesis of atherosclerotic cardiovascular disease,and recent advances in the treatment of atherosclerotic cardiovascular disease using intestinal flora as a target.