羧甲司坦联合茚达特罗格隆溴铵对老年AECOPD患者血气指标及呼吸困难程度的影响

Effects of carboxymesteine combined with indacatrolonium bromide on blood gas indexes and dyspnea degree in elderly patients with AECOPD

目的:观察羧甲司坦联合茚达特罗格隆溴铵对老年慢性阻塞性肺疾病急性加重(AECOPD)患者血气指标及呼吸困难程度的影响。方法:回顾性收集2022年3月~2023年3月期间我院收治的老年AECOPD患者80例,按照治疗方法不同分为对照组(n=40,茚达特罗格隆溴铵治疗)和研究组(n=40,羧甲司坦联合茚达特罗格隆溴铵治疗),观察患者血气分析指标、呼吸困难程度、临床疗效以及不良反应发生情况。结果:治疗3 d、7 d,两组PaO_(2)水平逐渐升高,PaCO_(2)水平逐渐降低,研究组PaO_(2)、PaCO_(2)水平变化优于对照组(P<0.05);两组呼吸困难程度评分逐渐下降,研究组明显低于对照组(P<0.05);研究组治疗总有效率明显高于对照组(P<0.05);两组患者不良反应发生率相近(P>0.05)。结论:羧司坦联合茚达特罗格隆溴铵对老年AECOPD患者有明显疗效,可调节患者血气指标,减轻患者呼吸困难程度,安全性较高。

Objective:To observe the effects of carboxymesteine combined with indacatrolonium bromide on blood gas indexes and dyspnea in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).How:A total of 80 elderly patients with AECOPD admitted to our hospital from March 2022 to March 2023 were retrospectively collected and divided into control group(n=40,indacatrolonium bromide treatment)and study group(n=40,carboxymesteine combined with indacatrolonium bromide treatment)according to different treatment methods.Blood gas analysis index,dyspnea degree,clinical efficacy and occurrence of adverse reactions were observed.Results:After 3 days and 7 days of treatment,PaO_(2) level was gradually increased and PaCO_(2) level was gradually decreased in two groups.The changes of PaO_(2) and PaCO_(2) in the study group were better than those in the control group(P<0.05).The dyspnea degree of the two groups decreased gradually,and the study group was significantly lower than the control group(P<0.05).The total effective treatment rate of the study group was significantly higher than that of the control group(P<0.05).The incidence of adverse reactions was similar between the two groups(P>0.05).Conclusion:Carbosteine combined with indacatrolonium bromide has obvious efficacy in elderly patients with AECOPD,can adjust the blood gas index of patients,reduce the degree of dyspnea of patients,and has high safety.