巨噬细胞极化在骨质疏松中调控作用及机制的研究进展

Research progress of the regulating role and mechanism of macrophage polarization in osteoporosis

骨质疏松症一直是备受关注的重点疾病之一。研究提示,巨噬细胞极化可能是影响骨质疏松症的重要机制之一。巨噬细胞极化过程中产生的细胞因子和激活的相关信号通路,与骨细胞、成骨细胞和破骨细胞等各种骨相关细胞相互作用,参与骨质疏松症的形成和转归。本文对巨噬细胞极化、表型转换的过程和调控机制,及其在骨愈合过程中的重要作用做综述,论述其治疗骨质疏松症的前景,为骨质疏松症靶点的选择提供新的思路。

Osteoporosis has been one of the major diseases that people pay attention to.Macrophage polarization may be one of the important mechanisms affecting osteoporosis.The cytokines produced during the process of macrophage polarization and the related signaling pathways activated interact with various bone-related cells such as osteocytes,osteoblasts and osteoclasts,and participate in the formation and outcome of osteoporosis.This paper mainly describes the generation and regulation mechanism of macrophage polarization and phenotypic transformation,summarizes its important role in the process of bone healing,discusses its prospects for the treatment of osteoporosis,and provides new ideas for the selection of osteoporosis targets.