摘要
Chromobox protein homolog 4(CBX4)is a component of the Polycomb group(PcG)multiprotein Polycomb repressive complexes 1(PRC1),which is participated in several processes including growth,senescence,immunity,and tissue repair.CBX4 has been shown to have diverse,even opposite functions in different types of tissue and malignancy in previous studies.
基金
The authors thank Dr.Kwok-Kin Wong for kindly providing the KrasG12D mice.This work was supported by the National Key R&D Program of China(2022YFA1106400 and 2020YFA0803201 to Z.W.)
The National Natural Science Foundation of China(32270886 and 32070827 to Z.W.,31971111 to C.L,31900811 to W.Y.)
The Natural Science Foundation of Guangdong Province of China(2021A1515010674 to W.Y.)
Key laboratory tasks(LG202103-01-07 to Z.W.).
