摘要
The mineral dust-induced gene(MDIG)comprises a conserved JmjC domain and has the ability to demethylate histone H3 lysine 9 trimethylation(H3K9me3),Previous studies have indicated the significance of MDIG in promoting cell proliferation by modulating cell-cycle transition.However,its involvement in liver regeneration has not been extensively investigated.In this study,we generated mice with liver-specific knockout of MDIG and applied partial hepatectomy or carbon tetrachloride mouse models to investigate the biological contribution of MDIG in liver regeneration.
基金
This work was supported by grants from the National multidisciplinary collaborative diagnosis and treatment capacity building project for major diseases(TJZ202104)
the Natural Science Foundation of China(81770615,82070644,82270643,81800564,and 82170621)
Science and Technology Major Program of Sichuan Province(2022ZDZX0019 and 2021YFS0048)
1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYJC18008 and ZYGD22006)。
