摘要
The role of gut microbiota in modulating the durability of cOVID-19 vaccine immunity is yet to be characterised.In this cohort study,we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline,1 month,and 6 months post vaccination(p.v).Neutralisation antibody,plasma cytokine and chemokines were measured and associated with the gut microbiota and metabolome composition.
基金
The study was supported by the Health and Medical Research Fund(HMRF)Commissioned Research Grant(COVID193002)(F.K.L.C.)
Enhanced start-up research grant of CUHK(H.M.T.)
Hui Hoy&Chow Sin Lan Charity Fund Limited(S.C.N.)
the National Research Foundation of Korea(NRF)grant funded through the Korea government(NRF-2018M3A9H4055203)(C.K.P.M.)
Emergency Key Program of Guangzhou Laboratory(Grant No.EKPG22-30-6)(C.K.P.M.).
