组织驻留记忆T细胞及其在三阴性乳腺癌中的研究进展

Research Progress on Tissue-Resident Memory T Cells and Their Role in Triple-Negative Breast Cancer

T淋巴细胞在实体肿瘤的抗肿瘤反应中起着重要作用,在多种实体肿瘤中,肿瘤特异性记忆T细胞可能在控制肿瘤细胞生长、限制肿瘤细胞扩散方面发挥重要作用。在三阴性乳腺癌中,肿瘤浸润淋巴细胞表现出与组织驻留记忆T细胞(tissue-resident memory T cells,TRM)相关的分子表型和免疫功能特征,包括组织特异性归巢分子和免疫衰竭标志物的表达。高水平TRM与三阴性乳腺癌患者更好的预后相关,表明TRM类似于肿瘤浸润淋巴细胞,可能有助于抗肿瘤反应。全文重点讨论CD8+TRM的特征及临床意义,以及靶向这些细胞以提高三阴性乳腺癌患者免疫治疗方法成功率的潜在途径。

T lymphocytes are the major immune cells in antitumor response,and tumor-specific memory T cells play an important role in controlling tumor cell growth and limiting tumor cell spread in a variety of solid tumors.In triple-negative breast cancer(TNBC),tumor-infiltrating lymphocytes(TILs)exhibit molecular phenotypes and immune functional features of tissue-resident memory T cells(TRM),including the expression of tissue-specific homing molecules and immune exhaustion markers.High levels of TRM are associated with better prognosis in TNBC patients,suggesting that TRMs may also contribute to the antitumor response.In this review,we mainly discuss the characteristics and clinical significance of CD8+TRM and potential ways to target these cells to improve the efficacy of immunotherapy in patients with triple-negative breast cancer.