微针射频联合盐酸米诺环素治疗面部中重度痤疮的临床研究

Observation and follow-up analysis of the therapeutic effect of microneedle radiofrequency combined with minocycline hydrochloride on facial moderate and severe acne

目的探索微针射频联合盐酸米诺环素治疗面部中重度痤疮的临床疗效。方法自2022年1—12月,淄博市妇幼保健院皮肤科门诊收治65例中重度痤疮患者,随机分为治疗组和对照组。对照组(35例)口服盐酸米诺环素6周治疗中重度痤疮;治疗组(30例)口服盐酸米诺环素6周联合微针射频治疗1次。在治疗前、治疗2周、治疗6周及治疗后12周拍照,采用痤疮综合分级系统量表(global acne grading system,GAGS)评分并比较,计算炎症性病变计数,记录相关不良反应发生情况、痤疮复发率情况。结果经治疗6周,治疗组有效率(86.6%)高于对照组(62.8%),差异有统计学意义(P<0.05);治疗后及随访时,两组GAGS评分均有改善,炎症性病变计数均减少,治疗组明显优于对照组,组间差异具有统计学意义(P<0.05);治疗后12周,治疗组复发率(19.2%)低于对照组(54.5%),差异有统计学意义(P<0.05)。两组均未出现明显不良反应。结论微针射频联合米诺环素治疗痤疮安全、有效、复发率较低,值得临床上推广应用。

Objective To explore the clinical efficacy of microneedle radiofrequency combined with minocycline hydrochloride in the treatment for facial moderate and severe acne.Methods From January 2022 to December 2022,65 patients with moderate to severe acne were randomly divided into a treatment group and a control group in the dermatology outpatient department of Zibo Maternal and Child Health Hospital.The control group(n=35)was given oral minocycline hydrochloride for 6 weeks for moderate to severe acne;the treatment group(n=30)was given oral minocycline hydrochloride for 6 weeks,and microneedle radiofrequency therapy was conducted once.Photos were taken before treatment,2 weeks,6 weeks and 12 weeks after the treatment.The global acne grading system(GAGS)was adopted to evaluate the efficacy and compare the scores between the two groups.The inflammatory lesion count was calculated,any related adverse reactions and acne recurrence were recorded during the follow-up care.Results After 6 weeks of treatment,the effective rate of the treatment group(86.6%)was significantly higher than that of the control group(62.8%);the difference was statistically significant(P<0.05).After treatment and during follow-up care,GAGS score and inflammatory lesion count were improved in both groups,and the treatment group was significantly better than the control group,with statistical significance(P<0.05).At 12 weeks of follow-up care,the recurrence rate in the treatment group(19.2%)was significantly lower than that in the control group(54.5%),the difference being statistically significant(P<0.05).The two groups had no obvious adverse reactions during the treatment and follow-up care.Conclusion The combination of minocycline and microneedles in the treatment of acne is safe,effective and has a low recurrence rate.