结核分枝杆菌的抗逆性与致病性研究进展

Research Progress on Antimicrobial Resistance and Pathogenicity of Mycobacterium tuberculosis

结核病是由结核分枝杆菌(Mycobacterium tuberculosis,MTB)复合群感染导致的人畜共患传染病,在新型冠状病毒感染暴发前是全球死亡人数最多的单一传染病。结核病致死率高,主要原因是其致病菌结核分枝杆菌具有极强的毒力且可以抵御多种外界环境胁迫因子。本文主要介绍结核分枝杆菌对理化胁迫的耐受性,以及结核分枝杆菌的耐药性、致病性与免疫性,为深入研究结核病的发病机制和研发新型的抗结核药物提供理论指导。

Tuberculosis is a zoonotic infectious disease caused by Mycobacterium tuberculosis(MTB)complex infection.Before the outbreak of novel coronavirus infection,it was the single infectious disease with the largest number of deaths in the world.The mortality rate of tuberculosis is high,and the main reason is that the pathogenic bacteria Mycobacterium tuberculosis has strong virulence and can resist a variety of external environmental stress factors.This article mainly introduces the tolerance of Mycobacterium tuberculosis to physical and chemical stress,the drug resistance of Mycobacterium tuberculosis,the pathogenicity and immunity of Mycobacterium tuberculosis,and provides theoretical guidance for in-depth study on the pathogenesis of tuberculosis and the research and development of new anti-tuberculosis drugs.