CGF联合Bio-Oss骨粉对自体骨环植骨同期种植术疗效及新骨形成的影响

Effect of CGF Combined with Bio-Oss Bone Powder on the Effi cacy and New Bone Formation of the Simultaneous Implantation of Autologous Bone Ring

目的:探讨浓缩生长因子(Concentrated growth factor,CGF)联合Bio-Oss骨粉在自体骨环植骨同期种植术中的应用效果。方法:选取笔者医院2019年1月-2020年12月收治的拟实施自体骨环植骨同期种植术的患者82例作为研究对象,采用随机数字表法分为A组和B组各41例,A组采用CGF联合Bio-Oss骨粉,B组仅给予Bio-Oss骨粉治疗。对比两组患者术后新生骨厚度、新生骨密度、种植体红色修复美学指标评分及1年随访结局情况。结果:术后1个月,A组显示新生骨痂由缺损边缘长入材料内部,且缺损边缘与材料紧密连接,界限模糊;B组显示新生骨痂,但在数量上明显少于A组。术后3个月,A组有一小部分材料被分割包绕,有崩解现象,新生骨长入材料内部;B组骨痂形成量有所增加,材料的密度降低,可见细小颗粒,但无崩解现象。术后6个月,A组材料被大部分吸收,种植体与材料接触紧密,界限模糊;B组新生骨生长缓慢,长入材料内部,植入材料体积变小,降解吸收不明显,未见种植体与材料紧密接触。术后1个月、3个月、6个月,两组患者的新生骨厚度值均呈逐渐增加的趋势(P<0.05),A组患者在术后1个月、3个月的新生骨厚度值均高于B组(P<0.05);术后1个月、3个月、6个月,两组患者的新生骨密度值均呈逐渐增加的趋势(P<0.05),A组患者在术后1个月、3个月的新生骨密度值均高于B组(P<0.05);术后3个月、6个月,A组患者的种植体红色修复美学评分均高于B组(P<0.05)。结论:CGF联合Bio-Oss骨粉有利于促进新生骨组织的形成,具有较好的修复美学效果。

Objective To explore the effect of concentrated growth factor(CGF)combined with Bio-Oss bone powder in the simultaneous implantation of autogenous bone ring.Methods A total of 82 patients(January 2019-December 2020)who were enrolled in the author's hospital for the simultaneous implantation of autogenous bone ring were selected as subjects.They were randomly divided into group A and group B by 41 cases.Group A was treated with CGF composite Bio-Oss bone powder,and group B was only treated with Bio-Oss bone powder.The new bone thickness,new bone mineral density,implant red repair aesthetic index and one-year follow-up outcome were compared between the two groups.Results One month after surgery,group A showed that the new callus grew into the material from the defect edge,and the defect edge was closely connected with the material,and the boundary was blurred.Group B showed new callus,but the number was significantly less than group A.3 months after surgery,A small part of the material in group A was segmented and wrapped,with disintegrating phenomenon and new bone growing into the material.In group B,callus formation increased,material density decreased andfine particles were observed,but no disintegration was observed.Six months after surgery,the material in group A was mostly absorbed,and the implant was in close contact with the material with blurred boundaries.In group B,the new bone grew slowly,grew into the material,the volume of the implant material became small,the degradation absorption was not obvious,and there was no close contact between the implant and the material.At 1 month,3 months,and 6 months after operation,the new bone thickness of the two groups showed a trend of increasing gradually(P<0.05).The patients in group A had new bone at 1 month and 3 months after operation.The thickness values were higher than those in group B(P<0.05).At 1 month,3 months,and 6 months after operation,the new bone mineral density values of the two groups increased gradually(P<0.05).Group A The values of new bone mineral density in patients at 1 month and 3 months after operation were higher than those in group B(P<0.05).At 3 months and 6 months after operation,the aesthetic red scores of implants in group A were higher than those in group B(P<0.05).Conclusion CGF combined with Bio-Oss bone powder is beneficial to promote the formation of new bone tissue and has a good aesthetic effect.