非编码RNA对瘢痕疙瘩形成的影响机制研究进展

Research Progress on the Mechanism of Influence of Non-coding RNA on Keloid Formation

瘢痕疙瘩是一种皮肤纤维增生性疾病,多由于伤口愈合过程中成纤维细胞增殖和胶原纤维沉积引起,瘢痕疙瘩的预防和治疗一直是整形外科领域的难题。目前,对瘢痕疙瘩发病机理的了解仍不够完整。本文通过对非编码RNA(lncRNA与miRNA)影响瘢痕疙瘩和增生性瘢痕形成的机制进行检索和归纳总结,以期为人瘢痕疙瘩的发生机制有更新、更全面的认识。

Keloid is a kind of skin fibroproliferative disease,which is mainly caused by fibroblast proliferation and collagen fi ber deposition in the process of wound healing.The prevention and treatment of keloid has always been a difficult problem in the field of plastic surgery.At present,the understanding of the pathogenesis of keloid is still incomplete.In this paper,we searched and summarized the mechanism of non coding RNA(lncRNA and miRNA)affecting keloid and hypertrophic scar formation,in order to have a newer and more comprehensive understanding of the mechanism of human keloid.