戊型肝炎:从幕后走到台前

Hepatitis E:From behind the scenes to the front stage

戊型肝炎是由HEV感染引起的病毒性肝炎。HEV主要有4种基因型,分别为基因1~4型。相较乙型肝炎和丙型肝炎,既往戊型肝炎相关研究进展较为缓慢。然而,近年来我国对于戊型肝炎关注度逐步升高,实现了从幕后走向台前。首先,我国人口基数较大,HEV感染人数多,疾病负担较重,因而需高度重视戊型肝炎预防、诊断和治疗。其次,世界卫生组织提出“于2030年全球消除病毒性肝炎”的宏伟目标,我国在乙型肝炎和丙型肝炎防治现已取得卓越成效。目前,我国戊型肝炎发病率和病死率已超过甲型肝炎,对戊型肝炎的积极有效防治意义重大。最后,国内戊型肝炎领域研究者自发组成中国戊型肝炎研究协助组,制定相关专家共识,建立国内外合作平台,进一步推动我国戊型肝炎相关研究热潮。

Hepatitis E is a type of viral hepatitis caused by hepatitis E virus(HEV)infection.There are four main genotypes of HEV,namely genotypes 1—4.Compared with hepatitis B and hepatitis C,previous research on hepatitis E has made slow progress;however,in recent years,hepatitis E has gradually attracted more attention in China,achieving the transition from behind the scenes to the front stage.First,China has a large population base,a large number of people infected with hepatitis E,and a heavy disease burden,and thus it is necessary to attach great importance to the prevention,diagnosis,and treatment of hepatitis E.Second,the World Health Organization(WHO)has put forward the ambitious goal of eliminating viral hepatitis by 2030,and China has made remarkable achievements in the prevention and treatment of hepatitis B and hepatitis C.At present,the incidence and mortality rates of hepatitis E in China have exceeded those of hepatitis A,and the prevention and treatment of hepatitis E in China is of great significance to actively respond to the call of the WHO.Finally,Chinese researchers in the field of hepatitis E have formed Chinese Consortium for the Study of Hepatitis E,formulated related expert consensus,and established international cooperation platforms,which further promotes the research on hepatitis E in China.