自身免疫性肝病肝纤维化无创诊断研究进展

Research advances in noninvasive diagnosis of liver fibrosis in autoimmune liver diseases

自身免疫性肝病(ALD)是一组由自身免疫反应介导的慢性炎症性肝病,可进展为肝纤维化、肝硬化甚至肝衰竭。ALD肝纤维化的早诊早治,动态随访,有助于改善疾病转归,甚至逆转早期肝硬化。由于肝活检存在局限性和潜在风险,寻找无创检测技术已成为肝纤维化领域的研究热点。本文综述了近年来与ALD肝纤维化相关的血清学标志物及影像学技术的研究进展,并分析了各种检测方法的优缺点及发展趋势。

Autoimmune liver diseases(ALD)are a group of chronic inflammatory liver diseases mediated by autoimmune response and can progress to liver fibrosis,liver cirrhosis,and even liver failure.Early diagnosis,early treatment,and dynamic follow-up of liver fibrosis in ALD may help to improve the prognosis of the disease and even reverse early-stage liver cirrhosis.Due to the limitations and potential risks of liver biopsy,the search for noninvasive techniques has become a research hotspot in the field of liver fibrosis.This article reviews the recent research advances in serum markers and imaging techniques for liver fibrosis in ALD and analyzes the advantages and disadvantages of each detection method and their development trends.