CREB通过调节突触可塑性调节记忆及与阿尔茨海默病的联系

Advances of CREB in the regulation of memory through synaptic plasticity and its relationship with Alzheimer’s disease

阿尔茨海默病(Alzheimer’s disease,AD)是一种发病机制复杂,不可逆转的神经退行性疾病。AD患者表现为记忆缺失,突触可塑性受损。本文关注与突触可塑性密切相关的环腺苷酸反应元件结合蛋白(cAMP responsive element-binding protein,CREB),总结CREB的结构、激活途径、下游基因及对记忆的调控作用,关注CREB与AD的联系,为基于神经可塑性的AD的研究提供参考。

Alzheimer’s disease(AD)is an irreversible heterogeneous neurodegenerative disease.AD patients have memory loss and impaired synaptic plasticity.In view of cAMP responsive element-binding protein(CREB),which is intimately associated with synaptic plasticity,this article summarizes the research progress on the structure,signaling pathways,downstream genes,and relative memory regulation.The involvement of CREB in AD development serves as a reference for AD researchers to improve synaptic plasticity.