独活寄生汤治疗骨科疾病的临床应用研究进展

Research progress on clinical application of Duhuo Jisheng Decoction in the treatment of orthopedic diseases

独活寄生汤通过抑制衰老相关蛋白染色质组装和调节复合体因子la(ASFla)、衰老蛋白组蛋白调节因子的表达、降低细胞色素C和一氧化氮水平及调节某些炎症因子来影响骨和软骨的合成和凋亡。独活寄生汤在不同骨创伤和重建中的应用实例证实其在腰腿痛、关节炎、肩周炎等骨科常见疾病的应用中有较好疗效。该文在对独活寄生汤药理分析的基础上,对其在治疗骨科疾病的临床应用方面进行综述。

Duhuo Jisheng Decoction affects the synthesis and apoptosis of bone and cartilage by inhibiting the expression of ASFla and HIRA,reducing the levels of cytochrome C and nitric oxide,and regulating some inflammatory factors.The application examples of Duhuo Jisheng Decoction in different bone trauma and reconstruction have confirmed that it has a good effect in the application of common orthopedic diseases such as lumbocrural pain,arthritis,and scapulohumeral periarthritis.Based on the pharmacological analysis of Duhuo Jisheng Decoction,this paper reviews the clinical application of Duhuo Jisheng Decoction in the treatment of orthopedic diseases.