肠道菌群与慢性阻塞性肺疾病的相关性研究进展

Research progress on the correlation between gut microbiota and chronic obstructive pulmonary disease

人体的微生物菌群在维持机体内环境稳态和机体的免疫系统中均起着重要作用。近几年,由于微生物代谢组学分析的发展,肠道微生物菌群和呼吸系统疾病之间的关系受到越来越多的关注和重视。而慢性阻塞性肺疾病(COPD)在呼吸系统疾病中占有重要部分,其发病机制复杂,具有高患病率、高致残率,并且仍具有不断上升的趋势,对全世界形成重大的疾病负担。“肠-肺轴”的提出为COPD发病机制的研究和治疗手段提供了新的思路和方向,该文将重点介绍肠道菌群与COPD相关性的研究进展。

The human microbial plays an important role in maintaining the homeostasis of the internal environment and the body′s immune system.In recent years,the relationship between gut microbiota and respiratory diseases has received more and more attention due to the development of microbial metabolomics analysis.Chronic obstructive pulmonary disease(COPD)is an important part of respiratory system diseases,with a complex pathogenesis,high incidence and disability rates,and a continuous up ward trend,forming a significant disease burden worldwide.The proposal of the“Gut-lung axis”provides a new idea and direction for the study of the pathogenesis and treatment of COPD.This article will focus on the research progress of the correlation between gut microbiota and COPD.