补阳还五汤对慢性脑供血不足患者血液流变学、血流动力学的影响

Effect of Buyang Huanwu Decoction on Hemorheology and Hemodynamics in Patients with Chronic Cerebral Insufficiency

目的探究补阳还五汤对慢性脑供血不足患者血液流变学、血流动力学的影响。方法收集2019年4月—2022年4月西安中医脑病医院收治的慢性脑供血不足患者88例,随机分为治疗组(44例,常规西药+补阳还五汤治疗)、对照组(44例,常规西药治疗),评估临床疗效,测量比较两组患者治疗前及治疗后血液流变学、血流动力学血清炎性因子变化情况,统计给药期间嗜睡、胃肠道不适、皮疹等不良反应发生情况。结果治疗组总有效率显著高于对照组(P<0.05);治疗后治疗组血浆黏度、红细胞压积均显著低于对照组(P<0.05);治疗后治疗组椎动脉、基底动脉、大脑中动脉平均血流速度显著高于对照组(P<0.05);治疗后治疗组血清白介素-23(interleukin-23,IL-23)、肿瘤坏死因子-α(Tumour necrosis factor-α,TNF-α)水平均显著低于对照组(P<0.05);治疗组与对照组不良反应发生率无显著差异(P>0.05)。结论给予慢性脑供血不足患者补阳还五汤联合常规西药治疗可显著改善其血液高凝状态,恢复颅内血液动力学,减轻炎症反应,提升整体疗效,且联合给药未见明显增毒表现。

Objective To explore the effect of Buyang Huanwu decoction on hemorheology and hemodynamics in patients with chronic cerebral blood supply insufficiency.Methods 88 patients with chronic cerebral ischemia admitted to our hospital from April 2019 to April 2022 were collected and randomly divided into a treatment group(44 cases,treated with conventional Western medicine and Buyang Huanwu decoction)and a control group(44 cases,treated with conventional Western medicine).Evaluate clinical efficacy,measure and compare changes in blood rheology,hemodynamics,and serum inflammatory factors between two groups of patients before and after treatment,and calculate the occurrence of adverse reactions such as drowsiness,gastrointestinal discomfort,and rash during the administration period.Results The total effective rate of the treatment group was significantly higher than that of the control group(P<0.05);After treatment,the plasma viscosity and hematocrit of the treatment group were significantly lower than those of the control group(P<0.05);After treatment,the average blood flow velocity of the vertebral artery,basilar artery,and middle cerebral artery in the treatment group was significantly higher than that in the control group(P<0.05);After treatment,the serum interleukin-23(IL-23)and tumour necrosis factor-α(TNF-α)levels in the treatment group were significantly lower than those in the control group(P<0.05);There was no significant difference in the incidence of adverse reactions between the treatment group and the control group(P>0.05).Conclusion The combination of Buyang Huanwu decoction and conventional Western medicine treatment can significantly improve the hypercoagulable state of blood,restore intracranial hemodynamics,reduce inflammatory reactions,and enhance overall efficacy in patients with chronic cerebral blood supply insufficiency.Moreover,the combination of medication has no significant toxic effect.