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子宫动脉栓塞术治疗子宫腺肌症患者的中期疗效评价及卵巢储备功能变化 被引量:1

Evaluation of mid-term efficacy and changes of ovarian reserve in patients with adenomyosis treated by uterine artery embolization
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摘要 目的:评价子宫动脉栓塞术(uterine artery embolization,UAE)治疗子宫腺肌症患者的中期效果及对卵巢储备功能的影响。方法:回顾性分析2019年2月—2021年6月期间在江南大学附属医院接受UAE治疗的36例子宫腺肌症患者的临床资料,对比UAE前及术后6个月时子宫体积、痛经程度、月经量及抗苗勒管激素(anti-Müllerian hormone,AMH)水平变化差异,并对术后妊娠情况进行分析。结果:(1)术前及术后6个月患者各项指标分别为子宫体积(220±45)、(155±23)mm3,痛经程度(120.4±12.3)、(45.3±7.8)分,月经量(120.36±12.26)、(45.3±7.86)mL,术后各指标均显著降低(P=0.013、0.001、0.002)。(2)UAE术前AMH水平与术后6个月相比,差异无统计学意义[(3.01±0.78)ng/mL vs(2.89±0.72)ng/mL,P=0.240]。(3)UAE术后患者的妊娠率约为36.11%(13/36),妊娠患者中足月生产率为53.85%(7/13),流产率为46.15%(6/13)。结论:UAE治疗子宫腺肌症不影响患者卵巢储备功能,是一种相对安全有效的治疗方式。 Objective:To evaluate the medium-term efficacy of uterine artery embolization(UAE)in the treatment of adenomyosis and the effects of ovarian reserve function.Methods:The clinical data of 36 patients with adenomyosis who were treated with UAE in Affiliated Hospital of Jiangnan University from February 2019 to June 2021 were analyzed retrospectively.The changes of uterine volume,dyspenorrhea,menstrual volume and anti-Müllerian hormone(AMH)levels before and 6 months after UAE were compared and analyzed,and the pregnancy status after operation was analyzed.Results:(1)The indexes of preoperative and six-months-postoperative patients were uterine volume(220±45),(155±23)mm3,dysmenorrhea degree(120.4±12.3),(45.3±7.8)points,menstrual volume(120.36±12.26),(45.30±7.86)mL respectively.Pairwise comparison of them shows significant decrease and the differences were statistically significant(P=0.013,0.001,0.002 respectively).(2)There was no significant difference in AMH level before UAE compared with 6 months after UAE[(3.01±0.78)ng/mL vs(2.89±0.72)ng/mL,P=0.240].(3)The pregnancy rate after UAE was 36.11%(13/36).In pregnancy patients,term productivity and abortion rate were 53.85%(7/13)and 46.15%(6/13)respectively.Conclusion:UAE is a relatively safe and effective treatment for adenomyosis without affecting ovarian reserve function.
作者 何玉洁 刘昌贺 李衡 袁艺文 吕正颀 吴清华 HE Yujie;LIU Changhe;LI Heng;YUAN Yiwen;LYU Zhengqi;WU Qinghua(Department of Radiology,Affiliated Hospital of Jiangnan University,Wuxi 214062;The Imaging College,Guizhou Medical University)
出处 《南通大学学报(医学版)》 2023年第5期443-446,共4页 Journal of Nantong University(Medical sciences)
基金 太湖高层次人才项目(BJ2020048),无锡市卫健委妇幼科研面上项目(FYKY201902)。
关键词 子宫腺肌症 子宫动脉栓塞术 抗苗勒管激素 卵巢储备功能 adenomyosis uterine artery embolization anti-Müllerian hormone ovarian reserve function
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