Ki-67、TEM1及ERCC1表达与胃癌新辅助化疗效果的相关性分析

Correlation analysis of expression levels of Ki-67,TEM1 and ERCC1 with the efficacy of neoadjuvant chemotherapy in gastric cancer patients

目的分析Ki-67、TEM1及ERCC1表达与胃癌新辅助化疗效果的相关性。方法回顾性分析2018年1月至2022年12月就诊并行胃癌新辅助化疗的112例胃腺癌患者为研究对象,收集患者临床病历资料,采用免疫组化技术检测胃镜活检和手术病理中Ki-67、TEM1及ERCC1的表达,分析与胃癌新辅助化疗效果相关的影响因素。结果胃癌新辅助化疗病理完全缓解16例(14.29%),有效68例(60.71%),无效44例(39.29%)。单因素分析:新辅助化疗有效率分别与T分期、临床分期、Ki-67表达、Ki-67变化、TEM1表达、ERCC1表达明显相关(P<0.05),病理完全缓解率分别与T分期、Ki-67表达、ERCC1表达明显相关(P<0.05)。多元Logistic回归分析:Ki-67表达、Ki-67变化、TEM1表达、ERCC1表达均是新辅助化疗有效的独立影响因素(P<0.05),Ki-67表达、ERCC1表达均是病理完全缓解的独立影响因素(P<0.05)。结论Ki-67、TEM1及ERCC1表达均是胃癌新辅助化疗效果的独立分子生物学预测因子,对胃癌新辅助化疗长期预后的判断具有一定的指导价值。

Objective To analyze the correlation of expression levels of Ki-67,tumor endothelial marker 1(TEM1)and excision repair cross-complementing group 1(ERCC1)with the efficacy of neoadjuvant chemotherapy in gastric cancer patients.Methods A total of 112 patients with gastric adenocarcinomas treated with neoadjuvant chemotherapy in our hospital from January 2018 to December 2022 were selected as the research subjects.The clinical data of patients were collected,and the expressions of Ki-67,TEM1 and ERCC1 in gastroscopic biopsy samples and surgical samples were detected by immunohistochemistry.Influencing factors for the efficacy of neoadjuvant chemotherapy in gastric cancer patients were analyzed.Results After neoadjuvant chemotherapy for gastric cancer,complete response,valid response and invalid response were achieved in 16 cases(14.29%),68 cases(60.71%)and 44 cases(39.29%),respectively.Univariable logistic regression analysis showed that the T stage,clinical staging,Ki-67 expression,Ki-67 changes,TEM1 expression and ERCC1 expression were significantly correlated with the effective rate of neoadjuvant chemotherapy in gastric cancer patients(P<0.05).T stage,Ki-67 expression and ERCC1 expression were significantly correlated with the complete response rate in gastric cancer patients(P<0.05).Multivariate analysis showed that Ki-67 expression,Ki-67 changes,TEM1 expression and ERCC1 expression were all independent influencing factors for the effectiveness of neoadjuvant chemotherapy in gastric cancer patients(P<0.05),while Ki-67 expression and ERCC1 expression were independent influencing factors for pathological complete response(P<0.05).Conclusion Expression levels of Ki-67,TEM1 and ERCC1 are independent biological predictors of neoadjuvant chemotherapy efficacy on gastric cancer,which provide certain guiding values for predicting the long-term prognosis of gastric cancer patients treated with neoadjuvant chemotherapy.