MMP-2和MMP-9在喉癌组织中的表达及其与预后的关系

Relationship between the expression of matrix metalloproteinase 2,9 and prognosis in laryngeal carcinoma

目的 :探讨基质金属蛋白酶 ( MMP)在喉癌中的表达情况。方法 :采用免疫组化染色方法检测了 45例喉癌患者 MMP- 2、MMP- 9的表达及二者与喉癌预后的关系。结果 :喉癌组织中MMP- 2和 MMP- 9的表达量明显高于癌旁和安全缘组织 ,MMP- 2、MMP- 9的表达在临床 、 期之间有显著差异 ,二者在无淋巴结转移的癌组织中表达较弱 ,在有淋巴结转移和复发的癌组织中表达较强 ;二者与喉癌病理分级无关。在 45例喉癌病人中对有 5年随访结果的 1 8例进行了统计学分析 ,结果 MMP- 2的表达强弱两组之间生存率有显著差异 ,而表达 MMP- 9的两组间差异无显著性。结论 :MMP- 2和 MMP- 9与喉癌的侵袭和转移密切相关 ;检测 MMP-

Objective:To understand the expressions of matrix metalloproteinase 2 and 9 in laryngeal carcinoma. Methods: Analyze the expressions of MMP 2 and MMP 9 in 45 cases with laryngeal carcinoma by immunohistochemistry and investigate the relationship between MMP 2 , MMP 9 expression and survival rate in 18 cases. Results:The expression of MMP 2 and MMP 9 were higher in tumor tissue than that in corresponding normal tissue. The tumoral expressions of MMP 2 and MMP 9 in clinical Ⅲ stage were higher than those in Ⅱ stage. The expression level of MMP 2 and MMP 9 in patients with lymph node metastasis were significantly higher than those with negative lymph node metastasis . The patients with high expression level of MMP 2 showed a significantly poorer 5 year survival rate than those with low expression level. Conclusion:The high level of MMP 2 and MMP 9 expressions are closely related to the invasion and metastasis of laryngeal carcinoma, and the higher expression level of MMP 2,the poorer prognosis.