微生态制剂治疗睡眠障碍的研究进展

Research progress in the treatment of sleep disorders with microecological preparations

睡眠障碍与代谢疾病、炎症疾病、心血管疾病、神经精神疾病等相关,是一个未受到充分重视的公共卫生问题。随着测序和多组学分析技术的发展,微生物-肠-脑轴在睡眠障碍中的作用逐渐受到重视,可能在睡眠障碍的病因和发病机制中起关键作用。微生态制剂调节肠道菌群已成为开发新的睡眠障碍疗法的一个潜在途径。该文总结了微生态制剂益生菌、益生元、合生元、后生元、菌群移植治疗睡眠障碍的研究进展,以期为临床治疗睡眠障碍寻找新的方法。目前微生态制剂中益生菌治疗睡眠障碍的研究最多,以乳杆菌和双歧杆菌为主。后生元可能在治疗睡眠障碍方面具有更大潜力。

Sleep disorders are associated with a variety of diseases including metabolic,inflammatory,cardiovascular,and neuropsychiatric disorders,and represent an underappreciated public health problem.With the development of sequencing and multi-omics technologies,the role of the microbiota-gut-brain axis in sleep disorders has been gradually recognized,and it may play a key part in the etiology and pathogenesis of sleep disorders.Regulating the gut microbiota with microecological preparations has become a promising approach for developing new therapies for sleep disorders.This review summarizes the advances in treating sleep disorders with microecological preparations such as probiotics,prebiotics,synbiotics,postbiotics,and fecal microbiota transplantation,in the hope of finding novel treatment methods for sleep disorders.Among them,probiotics are currently the most studied,with Lactobacillus and Bifidobacterium accounting for the majority.However,postbiotics may have a greater potential in the treatment of sleep disorders.